Compare chlorpromazine vs. loxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

chlorpromazine

loxapine

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Treats schizophrenia. Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it
Side effects
chlorpromazineloxapine

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The loxapine FDA package insert doesn’t have numbers about how common side effects are.

More about loxapine side effects »
How it works
chlorpromazineloxapine
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Loxitane (loxapine) is a typical antipsychotic. It works in the brain to calm down parts of the brain that might be responsible for aggressive behavior.
Type of medication
chlorpromazineloxapine
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
chlorpromazineloxapine
  • Pill
  • Injection
  • Pill
Used for
chlorpromazineloxapine
Risk factors for serious side effects
chlorpromazineloxapine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • People age 65 and older with dementia and psychosis
  • Taking antipsychotic medications
  • History of seizures
Detailed Loxitane (loxapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
chlorpromazineloxapine
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
Food
chlorpromazineloxapine
No food related info.
  • Take Loxitane (loxapine) with food to avoid stomach upset.
Sleep
chlorpromazineloxapine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
chlorpromazineloxapine
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
Downsides and risks
chlorpromazineloxapine
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
Tips from our pharmacists for people taking the medication
chlorpromazineloxapine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Don't drive or do anything requiring concentration until you know how Loxitane (loxapine) affects you since it can make you sleepy.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Be very careful getting up if you've been sitting or lying down for a while as Loxitane (loxapine) can cause changes in your blood pressure, which might make you more likely to faint or fall.
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about loxapineSide effectsAlternativesFDA package insert
Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it