Compare chlorpromazine vs. perphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Trilafon
(perphenazine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.
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Coupons for chlorpromazine
Best available price for 60 (25mg) tablets of chlorpromazine
Coupons for perphenazine
Best available price for 30 (4mg) tablets of perphenazine
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
Side effects
chlorpromazineperphenazine

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »
How it works
chlorpromazineperphenazine
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.
Type of medication
chlorpromazineperphenazine
Prescription onlyPrescription only
Available as
chlorpromazineperphenazine
  • Pill
  • Injection
  • Pill
Used for
chlorpromazineperphenazine
Risk factors for serious side effects
chlorpromazineperphenazine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlorpromazineperphenazine
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
Sleep
chlorpromazineperphenazine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
Weight
chlorpromazineperphenazine
No weight related info.
  • You're more likely to gain weight.
Upsides and benefits
chlorpromazineperphenazine
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
Downsides and risks
chlorpromazineperphenazine
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
Tips from our pharmacists for people taking the medication
chlorpromazineperphenazine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it