Compare chlorpromazine vs. perphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine (chlorpromazine)

Prescription only

Trilafon (perphenazine)

Prescription only
Stabilizes your mood.

Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.

Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Upsides
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
Downsides
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
Lowest price near you
$122.62
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Reviews
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Side effects
The Thorazine (chlorpromazine) FDA package insert doesn’t have numbers about how common side effects are.
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of death

    People over 65 with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Breathing problems

    Asthma

    ...and 2 more risk factors

  • Heat stroke and dehydration

    Benign prostatic hypertrophy (BPH)

    ...and 2 more risk factors

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Sleepiness

    Drinking alcohol or taking narcotics

See more detailed risks and warnings