Compare chlorpromazine vs. scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Transderm-Scop
(scopolamine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Prevents nausea and vomiting. Transderm-Scop (scopolamine) is a low-hassle patch that works well to prevent nausea and vomiting, but it takes several hours to work.
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Reviews for scopolamine
73%
-73% worse vs. chlorpromazine
58%
-58% worse vs. chlorpromazine
19%
+19% better vs. chlorpromazine
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
Side effects
chlorpromazinescopolamine

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
  • Dry mouth 12%
  • Dizziness 5%
  • Drowsiness 4%
  • Agitation 2%
  • Visual changes 2%
  • Confusion 1%
  • Dilated pupils 4%
  • Sore throat 1%
More scopolamine side effects »
How it works
chlorpromazinescopolamine
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Transderm-Scop (scopolamine) is an anti-nausea medicine. It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
chlorpromazinescopolamine
Prescription onlyPrescription only
Available as
chlorpromazinescopolamine
  • Pill
  • Injection
  • Patch
Used for
chlorpromazinescopolamine
Risk factors for serious side effects
chlorpromazinescopolamine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • Open angle glaucoma
  • Blockages in the stomach, bowels or bladder
  • MRI examination
  • History of seizures
  • History of psychosis
Detailed Transderm-Scop (scopolamine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlorpromazinescopolamine
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
No alcohol related info.
Sleep
chlorpromazinescopolamine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
Upsides and benefits
chlorpromazinescopolamine
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Transderm-Scop (scopolamine) is well tolerated.
  • Prevents nausea for 3 days.
  • Because Transderm-Scop (scopolamine) is a skin patch, it's a good alternative to stopping nausea and vomiting if you're not able to swallow pills.
Downsides and risks
chlorpromazinescopolamine
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Can only be used for prevention of nausea and vomiting. It can't stop nausea or vomiting that's already happening.
  • The side effects can be worse if you are 65 and older.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You're more likely to have heat stroke or feel dehydrated.
  • It takes a few hours for Transderm-Scop (scopolamine) to kick in, so you have to remember to take it beforehand.
Tips from our pharmacists for people taking the medication
chlorpromazinescopolamine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Starts working in 6 to 8 hours.
  • Apply Transderm-Scop (scopolamine) to a clean, dry, hairless area of the skin behind the ear. Press down for 30 seconds to make sure the patch stays firmly.
  • After handling the patch, make sure to wash your hands with soap and water to avoid accidental contact with your eyes.
  • If the patch comes off, throw it away and use a new patch.
  • You can prevent skin irritation by alternating ears and washing the area of your ear that you had placed the patch on.
  • If you're using this before surgery, place it the day before, then leave it on until the day after your surgery.
  • Take the patch off before you have an MRI because it can cause the skin to burn.
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about scopolamineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it