Compare chlorpromazine vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Chlorpromazine

Seroquel
(Quetiapine)

Coming soon.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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Reviews & ratings
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Reviews for Seroquel (Quetiapine)
52%
+52% vs. Chlorpromazine
46%
+46% vs. Chlorpromazine
28%
28% vs. Chlorpromazine
Side effects
chlorpromazineSeroquel

We haven’t found good data for chlorpromazine side effects.

FDA side effect reports for chlorpromazine »
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
How it works
chlorpromazineSeroquel
Coming soon.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
chlorpromazineSeroquel
Coming soon.
Antipsychotic
Atypical
Prescription only
Available as
chlorpromazineSeroquel
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
chlorpromazineSeroquel
  • Acute intermittent porphyria Apprehension
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about ChlorpromazineThe free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)
Risk factors for serious side effects
chlorpromazineSeroquel
Coming soon.
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Seroquel (Quetiapine) risks & warnings »
          Pregnancy category
          chlorpromazineSeroquel
          NFDA pregnancy category (Unknown)

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.
          • Can cause dizziness, drowsiness, and low blood pressure.
          Weight
          No specific weight-related info.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          Upsides and benefits
          chlorpromazineSeroquel
          Coming soon.
          • Effective at relieving psychotic symptoms and manic episodes.
          • Antipsychotic medicines are all about equally effective.
          • Fewer side effects than most antipsychotic medicines.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          Downsides and risks
          chlorpromazineSeroquel
          Coming soon.
          • In studies, less effective for people over age 40 for schizophrenia.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • You might need routine blood tests to check how the medicine is affecting your body.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          Tips from our pharmacists for people taking the medication
          chlorpromazineSeroquel
          Coming soon.
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Can cause dizziness, drowsiness, and low blood pressure.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          Learn more
          More about chlorpromazineSide effectsFDA package insert
          More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert