Compare chlorpromazine vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Seroquel
(quetiapine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.
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Coupons for chlorpromazine
Best available price for 60 (25mg) tablets of chlorpromazine
Coupons for Seroquel
Best available price for 30 (25mg) tablets of quetiapine
Reviews & ratings
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Reviews for Thorazine (chlorpromazine)
Not enough review data. Review it!
of people (All ages) say Thorazine (chlorpromazine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Reviews for Seroquel (quetiapine)
56%
+56% better vs. Thorazine (chlorpromazine)
50%
+50% better vs. Thorazine (chlorpromazine)
27%
-27% worse vs. Thorazine (chlorpromazine)
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
Side effects
chlorpromazineSeroquel

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »
How it works
chlorpromazineSeroquel
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
chlorpromazineSeroquel
Prescription only
Prescription only
Available as
chlorpromazineSeroquel
  • Pill
  • Injection
  • Pill
  • Extended release
Used for
chlorpromazineSeroquel
Risk factors for serious side effects
chlorpromazineSeroquel
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
chlorpromazineSeroquel
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
No alcohol related info.
Food
chlorpromazineSeroquel
No food related info.
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
chlorpromazineSeroquel
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause dizziness, drowsiness, and low blood pressure.
Weight
chlorpromazineSeroquel
No weight related info.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Upsides and benefits
chlorpromazineSeroquel
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides and risks
chlorpromazineSeroquel
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
chlorpromazineSeroquel
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about SeroquelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it