Compare chlorpromazine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Mellaril
(thioridazine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Treats schizophrenia. Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.
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Coupons for chlorpromazine
Best available price for 60 (25mg) tablets of chlorpromazine
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it
Side effects
chlorpromazinethioridazine

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The thioridazine FDA package insert doesn’t have numbers about how common side effects are.

More about thioridazine side effects »
How it works
chlorpromazinethioridazine
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Mellaril (thioridazine) is a typical antipsychotic that lowers levels of dopamine in the brain. In schizophrenia, it's believed the brain produces too much dopamine.
Type of medication
chlorpromazinethioridazine
Prescription onlyPrescription only
Available as
chlorpromazinethioridazine
  • Pill
  • Injection
  • Pill
Used for
chlorpromazinethioridazine
Risk factors for serious side effects
chlorpromazinethioridazine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • History of heartbeat problems
  • Taking medicines for depression
  • Taking beta blockers
  • People older than 65 years with dementia and psychosis
  • Long-term use of Mellaril (thioridazine)
Detailed Mellaril (thioridazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlorpromazinethioridazine
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Food
chlorpromazinethioridazine
No food related info.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
Sleep
chlorpromazinethioridazine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Mellaril (thioridazine) can make you feel sleepy the first few days that you take it, and you might be more likely to fall and hurt yourself. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you. Be very careful getting up if you've been sitting or lying down for a while, and brace yourself and sit down if you do feel dizzy.
Upsides and benefits
chlorpromazinethioridazine
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides and risks
chlorpromazinethioridazine
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
Tips from our pharmacists for people taking the medication
chlorpromazinethioridazine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Don't stop taking Mellaril (thioridazine) suddenly without talking to your doctor, even if you start to feel well.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
  • If you've missed a dose of Mellaril (thioridazine), take it as soon as you remember. But if it's time for your next dose, just take your normal amount and don't take extra medicine to make up for the missed dose.
  • Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about thioridazineSide effectsAlternativesFDA package insert
Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it