Compare chlorpromazine vs. thiothixene

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Navane
(thiothixene)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Treats schizophrenia. Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Navane (thiothixene)?
Worth itNot sureNot worth it
Side effects
chlorpromazinethiothixene

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The thiothixene FDA package insert doesn’t have numbers about how common side effects are.

More about thiothixene side effects »
How it works
chlorpromazinethiothixene
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Navane (thiothixene) is a typical antipsychotic. It works by lowering levels of dopamine in the brain. It's believed that schizophrenia might be caused by the brain being too sensitive to changes in dopamine.
Type of medication
chlorpromazinethiothixene
Prescription onlyPrescription only
Available as
chlorpromazinethiothixene
  • Pill
  • Injection
  • Pill
Used for
chlorpromazinethiothixene
Risk factors for serious side effects
chlorpromazinethiothixene
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
Detailed Navane (thiothixene) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlorpromazinethiothixene
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Don't drink alcohol while taking Navane (thiothixene).
Food
chlorpromazinethiothixene
No food related info.
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
Sleep
chlorpromazinethiothixene
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Navane (thiothixene) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how Navane (thiothixene) affects your concentration. This can be worse if you drink alcohol or take medicines that can make you sleepy, such as opioids for pain, benzodiazepines for anxiety, or medicines to help you sleep.
Weight
chlorpromazinethiothixene
No weight related info.
  • Side effects include weight gain and high blood sugar.
Upsides and benefits
chlorpromazinethiothixene
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
Downsides and risks
chlorpromazinethiothixene
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
Tips from our pharmacists for people taking the medication
chlorpromazinethiothixene
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Don't drive or do anything requiring concentration until you know how Navane (thiothixene) affects you.
  • You might not notice any changes in your behavior until you've taken Navane (thiothixene) for at least 4 weeks.
  • Navane (thiothixene) can cause low blood pressure. Be very careful getting up if you've been sitting or lying down for a while since you can feel faint.
  • Navane (thiothixene) can make it hard to control your body temperature. Be careful exercising, especially in the heat, and dress warmly if it's cold.
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
  • Don't drink alcohol while taking Navane (thiothixene).
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about thiothixeneSide effectsAlternativesFDA package insert
Have you used Navane (thiothixene)?
Worth itNot sureNot worth it