Compare chlorpromazine vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Zyprexa
(olanzapine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.
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Prices and coupon for 60 (25mg) tablets of chlorpromazine
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Prices and coupon for 30 (5mg) tablets of olanzapine
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Reviews for Zyprexa (olanzapine)
41%
+41% better vs. Thorazine (chlorpromazine)
51%
+51% better vs. Thorazine (chlorpromazine)
51%
-51% worse vs. Thorazine (chlorpromazine)
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Side effects
chlorpromazineZyprexa

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Positional low blood pressure 3%
  • Restlessness 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Muscle weakness 9%
  • Indigestion 6%
More Zyprexa side effects »
How it works
chlorpromazineZyprexa
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
chlorpromazineZyprexa
Prescription only
Prescription only
Available as
chlorpromazineZyprexa
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
Used for
chlorpromazineZyprexa
Risk factors for serious side effects
chlorpromazineZyprexa
  • People over 65 with dementia and psychosis
    • Taking antipsychotic medications
    • Asthma
    • COPD
    • Acute respiratory infections
    • Benign prostatic hypertrophy (BPH)
    • Urinary retention
    • Decreased movement in the intestines
    Detailed Thorazine (chlorpromazine) risks & warnings »
    • Elderly patients with dementia
        • History of heart problems
        • Drug interactions
          • People with diabetes
          • People with high cholesterol
          • People with diabetes
          • Alcohol
          • Taking other medicines that make you less alert
            Detailed Zyprexa (olanzapine) risks & warnings »
            Pregnancy

            The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Alcohol
            chlorpromazineZyprexa
            • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
            No alcohol related info.
            Food
            chlorpromazineZyprexa
            No food related info.
            • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
            • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
            Sleep
            chlorpromazineZyprexa
            • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
            • Might make you more sleepy than some antipsychotics.
            • Can cause dizziness and drowsiness.
            Weight
            chlorpromazineZyprexa
            No weight related info.
            • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
            • May cause weight gain and worsen cholesterol or blood sugar.
            • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
            Upsides and benefits
            chlorpromazineZyprexa
            • Acts fast to slow you down during a psychotic episode.
            • Can also be used for nausea or migraines.
            • Safe for use in children as young as 6 months.
            • Comes in a sugar-coated pill for easy administration.
            • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
            • Lowers relapse rates for schizophrenia and bipolar disorder.
            • Antipsychotic medicines are all about equally effective.
            • Less likely to cause heart problems than some antipsychotics.
            Downsides and risks
            chlorpromazineZyprexa
            • Has more side effects than other medicines like it.
            • Can affect how your other medicines work.
            • Makes you more sensitive to the sun.
            • Can make you dizzy or lightheaded, especially when injected.
            • Cannot be stopped right away.
            • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
            • Might make you more sleepy than some antipsychotics.
            • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
            • You might need routine blood tests to check how the medicine is affecting your body.
            • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
            Tips from our pharmacists for people taking the medication
            chlorpromazineZyprexa
            • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
            • Can cause involuntary muscle movements just like other medicines for your mood.
            • Can dry you out and make you more sensitive to the sun.
            • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
            • Cannot be stopped suddenly.
            • Takes 4 to 6 weeks to see full effects on thoughts and mood.
            • Can cause dizziness and drowsiness.
            • For the first week, avoid activities that require you to be alert.
            • May cause weight gain and worsen cholesterol or blood sugar.
            • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
            • Elderly people with dementia shouldn't take it.
            Learn more
            More about chlorpromazineSide effectsAlternativesFDA package insert
            Have you used Thorazine (chlorpromazine)?
            Worth itNot sureNot worth it
            More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Zyprexa (olanzapine)?
            Worth itNot sureNot worth it