Compare chlorthalidone vs. spironolactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thalitone
(chlorthalidone)

Aldactone
(spironolactone)

Lowers blood pressure. Removes extra water from your body. Thalitone (chlorthalidone) is a well-tolerated water pill that's increasingly used to treat high blood pressure.Removes extra water from your body. Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.
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Coupons for chlorthalidone
Best available price for 30 (25mg) tablets of chlorthalidone
Coupons for spironolactone
Best available price for 30 (25mg) tablets of spironolactone
Reviews & ratings
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Have you used Thalitone (chlorthalidone)?
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Have you used Aldactone (spironolactone)?
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Side effects
chlorthalidonespironolactone

The chlorthalidone FDA package insert doesn’t have numbers about how common side effects are.

More about chlorthalidone side effects »

The spironolactone FDA package insert doesn’t have numbers about how common side effects are.

More about spironolactone side effects »
How it works
chlorthalidonespironolactone
Thalitone (chlorthalidone) is a thiazide-like diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Aldactone (spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.
Type of medication
chlorthalidonespironolactone
Prescription onlyPrescription only
Available as
chlorthalidonespironolactone
  • Pill
  • Pill
Used for
chlorthalidonespironolactone
Risk factors for serious side effects
chlorthalidonespironolactone
  • History of gout
  • History of diabetes
  • History of kidney disease
  • History of acute kidney failure
  • History of azotemia
Detailed Thalitone (chlorthalidone) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
  • Current kidney problems
  • Taking other medicines that increase potassium
  • Use of salt substitutes
Detailed Aldactone (spironolactone) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
chlorthalidonespironolactone
  • Thalitone (chlorthalidone) works on the kidneys to help increase the amount of fluids removed from the body. This also causes a loss of electrolytes. Your doctor will perform routine blood tests to monitor your electrolyte levels.
  • Thalitone (chlorthalidone) can increase the kidney's retention of uric acid, which can increase your risk of gouty attacks. Let your doctor know if you have a history of gout.
  • Thalitone (chlorthalidone) works on the kidneys. For people with a history of kidney problems, this can put more pressure on your kidneys and make it harder for them to work. Let your doctor know if you have a history of kidney disease.
  • Requires routine blood tests to check your kidney function.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
Pain
chlorthalidonespironolactone
No pain related info.
  • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
Upsides and benefits
chlorthalidonespironolactone
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A good blood pressure treatment for people who haven't responded well to other thiazide diuretics. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
Downsides and risks
chlorthalidonespironolactone
  • Makes you urinate more often.
  • Doesn't work well in people with severe kidney problems.
  • Since Thalitone (chlorthalidone) works longer in the body than other thiazide diuretics, it has a higher chance of causing electrolyte changes.
  • Thalitone (chlorthalidone) can lead to more gouty attacks in people with gout.
  • Don't use this if you have a sulfa allergy.
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
Tips from our pharmacists for people taking the medication
chlorthalidonespironolactone
  • Take Thalitone (chlorthalidone) in the morning with a meal. It starts working in two hours, so don't take it at night; otherwise you'll go to the bathroom more overnight.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, tiredness, or muscle weakness that doesn't go away.
  • Requires routine blood tests to check your kidney function.
  • Your skin will be more sensitive to the sun while taking this, so don't forget to use sunscreen.
  • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
  • Don't use supplements or salt substitutes that are high in potassium.
  • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
  • Tell your doctor about any muscle weakness, skin changes, and red or black tarry stool.
  • You will urinate more often within 2 to 3 days, and will have lower blood pressure in 2 to 3 weeks.
Learn more
More about chlorthalidoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Thalitone (chlorthalidone)?
Worth itNot sureNot worth it
More about spironolactoneSide effectsAlternativesFDA package insert
Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it