Compare Cimzia vs. Arava

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia
(certolizumab)

Arava
(leflunomide)

Calms the immune system and prevents joint damage. Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.Coming soon.
Reviews & ratings
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Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it

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Have you used Arava (leflunomide)?
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Side effects
CimziaArava
  • Infections 8%
  • Upper airway infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
  • Sore throat 2%
More Cimzia side effects »

We haven’t found good data for Arava side effects.

FDA side effect reports for Arava »
How it works
CimziaArava
Cimzia (certolizumab) blocks a protein called TNF (tumor necrosis factor) that causes inflammation.Coming soon.
Type of medication
CimziaArava
Prescription only
Available as
CimziaArava
  • Injection
  • Pill
Used for
CimziaArava
  • Rheumatoid Arthritis
Risk factors for serious side effects
CimziaArava
  • Taking other immunosuppressant medications such as methotrexate or steroids
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)
Detailed Cimzia (certolizumab) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Upsides and benefits
    CimziaArava
    • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
    • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
    • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
    • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
    • Cimzia (certolizumab) has been on the market for almost 10 years.
    Coming soon
    Downsides and risks
    CimziaArava
    • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
    • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
    • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
    • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
    • There's no generic available and it can be expensive.
    Coming soon
    Tips from our pharmacists for people taking the medication
    CimziaArava
    • Cimzia (certolizumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so.
    • Each time you use Cimzia (certolizumab), it's important to rotate the sites you chose to inject it in. Don't inject Cimzia (certolizumab) into skin that's red, bruised, or irritated.
    • Keep Cimzia (certolizumab) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
    • Cimzia (certolizumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
    • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
    • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container and not in the trash.
    Coming soon
    Learn more
    More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Cimzia (certolizumab)?
    Worth itNot sureNot worth it
    More about AravaSide effectsReviews & ratingsFDA package insert
    Have you used Arava (leflunomide)?
    Worth itNot sureNot worth it