Compare Cimzia vs. Arava

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia
(certolizumab)

Arava
(leflunomide)

Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.Coming soon.
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Prices and coupon for 1 (starter of 200mg/ml) kit of certolizumab
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Prices and coupon for 30 (20mg) tablets of leflunomide
Reviews & ratings
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Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it

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Have you used Arava (leflunomide)?
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Side effects
CimziaArava
  • Any side effect 1%
  • Upper respiratory infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Ear, nose, or throat infection 4%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
More Cimzia side effects »

We haven’t found good data for Arava side effects.

FDA side effect reports for Arava »
How it works
CimziaArava
Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).Coming soon.
Type of medication
CimziaArava
Prescription only
Available as
CimziaArava
  • Injection
  • Pill
Used for
CimziaArava
  • Rheumatoid Arthritis
Risk factors for serious side effects
CimziaArava
  • Medications that lower immune system function
  • Younger age
      • History of heart failure
        Detailed Cimzia (certolizumab) risks & warnings »
        Coming soon.
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Upsides and benefits
        CimziaArava
        • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
        • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
        • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
        • Available in a prefilled syringe. This can make it easier to give yourself the injection.
        Coming soon
        Downsides and risks
        CimziaArava
        • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
        • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
        • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
        • Requires routine tests to check for infections.
        • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
        • There's no generic available and it can be very expensive.
        Coming soon
        Tips from our pharmacists for people taking the medication
        CimziaArava
        • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
        • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
        • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
        • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
        • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
        Coming soon
        Learn more
        More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Cimzia (certolizumab)?
        Worth itNot sureNot worth it
        More about AravaSide effectsReviews & ratingsFDA package insert
        Have you used Arava (leflunomide)?
        Worth itNot sureNot worth it