Compare Cimzia vs. Enbrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia
(Certolizumab)

Enbrel
(Etanercept)

Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
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Reviews & ratings
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Reviews for Enbrel (Etanercept)
58%
6% vs. Cimzia (Certolizumab)
52%
3% vs. Cimzia (Certolizumab)
19%
19% vs. Cimzia (Certolizumab)
Side effects
CimziaEnbrel
  • Upper respiratory infections 7%
  • Common cold 4%
  • Ear, nose, or throat infection 4%
  • High blood pressure 3%
  • Back pain 3%
  • Joint pain 2%
  • Acute bronchitis 2%
  • Rash 2%
  • Sore throat 2%
  • Urinary tract infections 1%
More Cimzia side effects »
  • Injection site reactions 26%
  • Any infection 11%
  • Positive anti-double-stranded dna antibodies 11%
  • Upper respiratory infections 8%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
  • Itching 1%
  • Rash 1%
More Enbrel side effects »
How it works
CimziaEnbrel
Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
CimziaEnbrel
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
CimziaEnbrel
  • Injection
  • Injection
Used for (click to learn more)
CimziaEnbrel
Risk factors for serious side effects
CimziaEnbrel
  • Medications that lower immune system function
  • Younger age
      • History of heart failure
        Detailed Cimzia (Certolizumab) risks & warnings »
          • History of heart failure
          • Taking other immunosuppressant drugs
          • Age 60 or older
          • Taking other immunosuppressant drugs
          • History of malignancy
          • History of neurologic condition
            Detailed Enbrel (Etanercept) risks & warnings »
            Pregnancy category
            CimziaEnbrel
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            No specific food-related info.No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
            • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers. Talk to your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
            • Enbrel (Etanercept) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Enbrel (Etanercept). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
            Upsides and benefits
            CimziaEnbrel
            • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
            • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
            • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
            • Available in a prefilled syringe. This can make it easier to give yourself the injection.
            • Treats certain types of arthritis conditions caused by an overactive immune system.
            • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
            • It has an established safety profile for treatment of rheumatoid arthritis (RA).
            • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
            • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
            Downsides and risks
            CimziaEnbrel
            • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
            • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
            • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
            • Requires routine tests to check for infections.
            • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
            • There's no generic available and it can be very expensive.
            • It's an injection.
            • It's expensive because there's no generic available yet.
            • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
            • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
            • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
            • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
            Tips from our pharmacists for people taking the medication
            CimziaEnbrel
            • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
            • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
            • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
            • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
            • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
            • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
            • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
            • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
            • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
            • You'll need to have a TB test before you start using Enbrel (Etanercept).
            • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
            • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
            • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
            Learn more
            More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
            More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert