Compare Cimzia vs. methotrexate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia (certolizumab)

Prescription only

Otrexup (methotrexate)

Prescription only
Calms the immune system and prevents joint damage.

Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.

Reduces inflammation and cell replication.

Otrexup (methotrexate) is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.

Upsides
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • Otrexup (methotrexate) is available as an affordable generic form.
  • Otrexup (methotrexate) comes as a tablet, an injection that you give yourself, or an infusion that you get in the doctor's office or infusion center.
Downsides
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • You may need frequent blood tests for monitoring when taking Otrexup (methotrexate).
  • Otrexup (methotrexate) can cause serious birth defects so women should avoid getting pregnant for at least 6 month and men 3 months after taking it.
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
Used for
Dosage forms
  • Injection
  • Pill
  • Injection
  • Liquid
Price
Lowest price near you
$3941.95
Find instant savings
Lowest price near you
$31.32
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
The Cimzia (certolizumab) FDA package insert doesn’t have numbers about how common side effects are.
The Otrexup (methotrexate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as methotrexate or steroids

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)

    ...and 2 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Multiple sclerosis

    ...and 1 more risk factors

See more detailed risks and warnings
  • Worsening side-effects

    Reduced kidney function

    ...and 2 more risk factors

  • Use of NSAIDs

    NSAIDS

    ...and 1 more risk factors

  • Liver problems

    Long-term use

    ...and 1 more risk factors

  • Diarrhea and mouth sores

    Taking Otrexup (methotrexate) with high-dose NSAIDs

  • Tumor lysis syndrome

    Rapidly growing tumors

  • Skin and bone tissue deterioration

    Radiotherapy

See more detailed risks and warnings