› People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
› Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
› You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
› After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
› Cimzia (certolizumab) has been on the market for almost 10 years.
› In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
› Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
› Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
› You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
› Available in a prefilled autoinjector for convenient use.
Downsides and risks
› Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
› Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
› In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
› Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
› There's no generic available and it can be expensive.
› Orencia (abatacept) can be costly.
› The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
› The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
› If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
› Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
Tips from our pharmacists for people taking the medication
› Cimzia (certolizumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so.
› Each time you use Cimzia (certolizumab), it's important to rotate the sites you chose to inject it in. Don't inject Cimzia (certolizumab) into skin that's red, bruised, or irritated.
› Keep Cimzia (certolizumab) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
› Cimzia (certolizumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
› If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
› As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container and not in the trash.
› If you are using the IV version of Orencia (abatacept), you will only need to get infusions once a month (after the first initial doses). It takes about 30 minutes to give the full dose of medicine. Stay hydrated and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
› The self-injections are taken once a week. You or your caregiver should receive training on the proper way to prepare and inject Orencia (abatacept).
› Keep the Orencia (abatacept) self-injection refrigerated, and let it rest at room temperature for 30 minutes before using it.
› Each time you use Orencia (abatacept), it's important to rotate the sites you chose to inject it in. Don't inject Orencia (abatacept) into skin that's red, bruised, or irritated.
› Talk with your doctor before getting any vaccines. Use of this drug may either raise the chance of an infection or make the vaccine not work as well.
› As with all injection medicines, store it securely away from children and throw away used syringes in an FDA-approved sharps disposal container, never in the trash.