Compare Cimzia vs. Orencia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia (certolizumab)

Prescription only

Orencia (abatacept)

Prescription only
Calms the immune system and prevents joint damage.

Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.

Calms down the immune system and prevents joint damage.

Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.

Upsides
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
  • Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
  • Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
  • You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
  • Available in a prefilled autoinjector for convenient use.
Downsides
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • Orencia (abatacept) can be costly.
  • The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
  • The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
  • If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
  • Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
Used for
Dosage forms
  • Injection
  • Infusion
  • Injection
Price
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$3941.95
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Lowest price near you
$3912.13
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Reviews
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Side effects
The Cimzia (certolizumab) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
    18%
  • Common cold
    12%
  • Dizziness
    9%
  • Cough
    8%
  • Back pain
    7%
  • High blood pressure
    7%
  • Indigestion
    6%
  • Urinary tract infection
    6%
  • Rash
    4%
  • Pain in arms or legs
    3%
See more detailed side effects
Risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as methotrexate or steroids

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)

    ...and 2 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Multiple sclerosis

    ...and 1 more risk factors

See more detailed risks and warnings
  • High risk of infections with TNF inhibitors

    Using TNF inhibitors

  • Immunosuppression and Infections

    Taking immunosuppressive medications

    ...and 2 more risk factors

  • More COPD side effects

    COPD

See more detailed risks and warnings