Compare Cimzia vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia (certolizumab)

Prescription only

Rituxan (Rituximab)

Prescription only
Calms the immune system and prevents joint damage.

Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.

Calms down your immune system.

Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.

Upsides
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • Treats leukemia, lymphoma, and blood vessel inflammation.
  • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
  • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
  • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
Downsides
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
  • Not the best choice if you have heart problems.
  • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Used for
Dosage forms
  • Injection
  • Infusion (iv)
Price
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$3941.95
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Reviews
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Side effects
The Cimzia (certolizumab) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Any infection
    62%
  • Infusion reaction
    12%
  • Any serious infection
    11%
  • Cardiac side effect
    2%
See more detailed side effects
Risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as methotrexate or steroids

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)

    ...and 2 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Multiple sclerosis

    ...and 1 more risk factors

See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Nervous system effects

    Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)

    ...and 2 more risk factors

  • Kidney injury

    Taking Rituxan (Rituximab) for Non-Hodgkin's Lymphoma (NHL)

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Gastrointestinal problems

    Start of therapy with Rituxan (Rituximab)

See more detailed risks and warnings