Compare Cimzia vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia
(certolizumab)

Rituxan
(rituximab)

Calms the immune system and prevents joint damage. Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.Calms down your immune system. Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.
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Coupons for Cimzia
Best available price for 1 (starter of 200mg/ml) kit of cimzia
Coupons for Rituxan
Best available price for 10 (10ml of 10mg/ml) vials of rituximab
Reviews & ratings
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Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it

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Have you used Rituxan (rituximab)?
Worth itNot sureNot worth it
Side effects
CimziaRituxan
  • Infections 8%
  • Upper airway infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
  • Sore throat 2%
More Cimzia side effects »
  • Fever 60%
  • Lung disorder 31%
  • Cardiac disorder 28%
  • Chills 13%
  • Any infection 62%
  • Infusion reaction 12%
  • Any serious infection 11%
  • Cardiac side effect 1%
  • Tested positive for haca 23%
More Rituxan side effects »
How it works
CimziaRituxan
Cimzia (certolizumab) blocks a protein called TNF (tumor necrosis factor) that causes inflammation.Rituxan (Rituximab) is a monoclonal antibody. It targets a specific protein on white blood cells that makes it easier for your immune system to find and destroy cancerous cells. It also relieves symptoms and slows the progression of Rheumatoid Arthritis.
Type of medication
CimziaRituxan
Prescription onlyPrescription only
Available as
CimziaRituxan
  • Injection
  • Infusion (iv)
Used for
CimziaRituxan
Risk factors for serious side effects
CimziaRituxan
  • Taking other immunosuppressant medications such as methotrexate or steroids
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)
Detailed Cimzia (certolizumab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
  • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
  • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
Detailed Rituxan (rituximab) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
CimziaRituxan
No kidneys and liver related info.
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Upsides and benefits
CimziaRituxan
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • Treats leukemia, lymphoma, and blood vessel inflammation.
  • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
  • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
  • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
Downsides and risks
CimziaRituxan
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
  • Not the best choice if you have heart problems.
  • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Tips from our pharmacists for people taking the medication
CimziaRituxan
  • Cimzia (certolizumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so.
  • Each time you use Cimzia (certolizumab), it's important to rotate the sites you chose to inject it in. Don't inject Cimzia (certolizumab) into skin that's red, bruised, or irritated.
  • Keep Cimzia (certolizumab) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
  • Cimzia (certolizumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container and not in the trash.
  • Rituxan (Rituximab) is given as an IV infusion by trained medical staff in a clinic or hospital.
  • You'll need to be monitored in the clinic in case you have a serious or life-threatening reaction during the infusion, but you can take other medications that'll lower your risk of this happening.
  • It's very important that you read the Medication Guide before you start taking Rituxan (Rituximab).
  • Rituxan (Rituximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, a cough that doesn't go away, or flu-like symptoms.
  • Use effective birth control while you're taking Rituxan (Rituximab) and for 12 months after you finish treatment.
  • Don't get live vaccines while you're taking Rituxan (Rituximab).
Learn more
More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
More about RituxanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rituxan (rituximab)?
Worth itNot sureNot worth it