Compare Cimzia vs. Simponi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cimzia
(certolizumab)

Simponi
(golimumab)

Calms the immune system and prevents joint damage. Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.Calms down the immune system. Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.
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Reviews & ratings
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Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it

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Have you used Simponi (golimumab)?
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Side effects
CimziaSimponi
  • Infections 8%
  • Upper airway infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
  • Sore throat 2%
More Cimzia side effects »
  • Common cold 3%
  • Injection site reaction 4%
  • Viral infections (such as influenza and herpes) 2%
  • Increased liver function test (alt) 1%
  • Increased liver function test (ast) 1%
  • High blood pressure 1%
  • Bronchitis 1%
  • Superficial fungal infections 1%
  • Tingling sensation 1%
  • Dizziness 1%
More Simponi side effects »
How it works
CimziaSimponi
Cimzia (certolizumab) blocks a protein called TNF (tumor necrosis factor) that causes inflammation.Simponi (golimumab) blocks a protein called TNF (tumor necrosis factor) that revs up the immune system. Blocking TNF lowers inflammation, relieves symptoms and prevents disease progression. Simponi (golimumab) is also known as a biologic DMARD (disease-modifying anti-rheumatic drug) - or just a "biologic" - when used to treat rheumatoid arthritis.
Type of medication
CimziaSimponi
Prescription onlyPrescription only
Available as
CimziaSimponi
  • Injection
  • Injection
Used for
CimziaSimponi
Risk factors for serious side effects
CimziaSimponi
  • Taking other immunosuppressant medications such as methotrexate or steroids
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)
Detailed Cimzia (certolizumab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • History of malignancy
Detailed Simponi (golimumab) risks & warnings »
Pregnancy
Upsides and benefits
CimziaSimponi
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides and risks
CimziaSimponi
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
Tips from our pharmacists for people taking the medication
CimziaSimponi
  • Cimzia (certolizumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so.
  • Each time you use Cimzia (certolizumab), it's important to rotate the sites you chose to inject it in. Don't inject Cimzia (certolizumab) into skin that's red, bruised, or irritated.
  • Keep Cimzia (certolizumab) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
  • Cimzia (certolizumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container and not in the trash.
  • Simponi (golimumab) is an immunosuppressant medication that's injected under the skin (subcutaneous) once a month.
  • Simponi (golimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Simponi (golimumab), it's important to rotate the sites you chose to inject it in (either your abdomen, thigh, or upper arm). Don't inject Simponi (golimumab) into skin that's red, bruised, or irritated.
  • Keep it refrigerated, and let it sit at room temperature for about 30 minutes before injecting yourself. Do not shake the Simponi (golimumab) autoinjector at any time.
  • People taking Simponi (golimumab) should not get live vaccines. Talk to your doctor before receiving any vaccines.
Learn more
More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
More about SimponiSide effectsAlternativesFDA package insert
Have you used Simponi (golimumab)?
Worth itNot sureNot worth it