Compare Cipro vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cipro
(ciprofloxacin)

Cleocin T
(clindamycin phosphate)

Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Cipro
Reviews for Cipro
63%
of people (All ages) say Cipro is worth it
53%
say it works well
17%
say it's a big hassle
755 reviews
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
Reviews for Cleocin
57%
+6% better vs. Cipro
43%
+10% better vs. Cipro
19%
+2% better vs. Cipro
115 reviews
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
Side effects
CiproCleocin
  • Any musculosketal side effect 14%
  • Any side effect 41%
  • Any musculoskeletal side effect 9%
  • Any neurological side effect 3%
  • Nausea 3%
  • Diarrhea 2%
  • Any gastrointestinal side effect 15%
  • Any serious side effect 8%
  • Vomiting 5%
  • Abdominal pain 3%
More Cipro side effects »
  • Any side effect 21%
  • Vaginal moniliasis 8%
  • Vulvovaginitis 6%
  • Vulvovaginal disorder 3%
  • Moniliasis (body) 2%
  • Fungal infection 2%
More Cleocin side effects »
How it works
CiproCleocin
Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
CiproCleocin
Prescription onlyPrescription only
Available as
CiproCleocin
  • Pill
  • Extended release
  • Infusion (iv)
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for
CiproCleocin
Risk factors for serious side effects
CiproCleocin
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • Myasthenia gravis
Detailed Cipro (ciprofloxacin) risks & warnings »
  • History of liver disease
Detailed Cleocin T (clindamycin phosphate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
CiproCleocin
No food related info.
  • Can be taken with or without food.
Kidneys and liver
CiproCleocin
No kidneys and liver related info.
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
Pain
CiproCleocin
  • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
  • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
  • If you notice pain in your Achilles tendons, contact your doctor.
  • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
Upsides and benefits
CiproCleocin
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Available in generic.
  • Topical form treats acne.
  • Available in different oral forms: tablet, capsule, and suspension.
  • Available in forms to treat skin infections and vaginal infections.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
Downsides and risks
CiproCleocin
  • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
  • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
  • Ciprofloxacin can make your skin more sensitive to the sun.
  • Can't be used if you've ever had myasthenia gravis.
  • Can cause diarrhea.
  • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
  • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
  • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
  • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
  • If you're taking the topical form, it can cause sensitivity and irritation.
Tips from our pharmacists for people taking the medication
CiproCleocin
  • If you notice pain in your Achilles tendons, contact your doctor.
  • Wear sunscreen if you're going to be out in the sun.
  • Take the medication exactly how the doctor tells you to.
  • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
  • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
  • Can cause diarrhea, nausea or vomiting.
  • Limit your caffeine intake while taking this medication.
  • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
  • Take this medication exactly how your doctor tells you to.
  • Store the suspension at room temperature.
  • If you're using the topical form, it can take a few weeks to see the full effect.
  • Keep the topical form out of your eyes, nose and mouth.
  • If you're using the topical form, Don't put makeup or bandages over it.
  • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
Learn more
More about CiproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it