Compare Cipro vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cipro
(Ciprofloxacin)

Vibramycin
(Doxycycline)

Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.180965147453083Cipro
Reviews for Cipro (Ciprofloxacin)
64%
of people say Cipro (Ciprofloxacin) is worth it
53%
say it works well
17%
say it's a big hassle
Reviews for Vibramycin (Doxycycline)
50%
14% vs. Cipro (Ciprofloxacin)
34%
19% vs. Cipro (Ciprofloxacin)
23%
6% vs. Cipro (Ciprofloxacin)
Side effects
CiproDoxycycline

The Cipro FDA package insert doesn’t have numbers about how common side effects are.

More about Cipro side effects »

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »
How it works
CiproDoxycycline
Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
CiproDoxycycline
Antibiotic
Fluoroquinolone
Prescription only
Antibiotic
Tetracycline
Prescription only
Available as
CiproDoxycycline
  • Pill
  • Extended release
  • Infusion (IV)
  • Pill
  • Delayed release capsule
  • Liquid
Used for (click to learn more)
CiproDoxycycline
Risk factors for serious side effects
CiproDoxycycline
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • Myasthenia gravis
        Detailed Cipro (Ciprofloxacin) risks & warnings »
        • Age 8 years or younger
        • Using oral birth control pills
        • Long antibiotic treatment period
            • Women of childbearing age
            • Women of childbearing age
            • Overweight or obese
            • Taking isotretinoin (Accutane)
            Detailed Vibramycin (Doxycycline) risks & warnings »
            Pregnancy category
            CiproDoxycycline
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            No specific food-related info.
            • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
            • Take with plenty of food and liquids.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            CiproDoxycycline
            • Available in generic.
            • Available in different forms: tablet, capsule, and suspension.
            • Used to treat many types of bacterial infections.
            • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
            • Available in generic.
            • Available in different forms: tablet, capsule, and suspension.
            • Used to treat many types of bacterial infections.
            • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
            Downsides and risks
            CiproDoxycycline
            • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
            • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
            • Ciprofloxacin can make your skin more sensitive to the sun.
            • Can't be used if you've ever had myasthenia gravis.
            • Can cause diarrhea.
            • Can't be used in pregnant women and children under 8 years old.
            • Makes your skin more sensitive to the sun.
            • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
            • Can make birth control less effective.
            • Can cause diarrhea.
            Tips from our pharmacists for people taking the medication
            CiproDoxycycline
            • If you notice pain in your Achilles tendons, contact your doctor.
            • Wear sunscreen if you're going to be out in the sun.
            • Take the medication exactly how the doctor tells you to.
            • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
            • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
            • Limit your caffeine intake while taking this medication.
            • Can cause diarrhea, nausea or vomiting.
            • Take the medication exactly how your doctor tells you to.
            • If you're using birth control pills, this medication can make them less effective.
            • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
            • Space out any vitamins by at least two hours.
            • Take with plenty of food and liquids.
            • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
            • Don't lie down for at least 30 minutes after taking this medication.
            • Can cause diarrhea, nausea or vomiting.
            Learn more
            More about CiproSide effectsReviews & ratingsAlternativesFDA package insert
            More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert