Compare Cipro vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cipro
(ciprofloxacin)

Vibramycin
(doxycycline)

Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
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Reviews & ratings
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5.17Cipro
Reviews for Cipro (ciprofloxacin)
63%
of people (All ages) say Cipro (ciprofloxacin) is worth it
53%
say it works well
17%
say it's a big hassle
755 reviews
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
Reviews for Vibramycin (doxycycline)
49%
-14% worse vs. Cipro (ciprofloxacin)
36%
-17% worse vs. Cipro (ciprofloxacin)
24%
-7% worse vs. Cipro (ciprofloxacin)
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Side effects
CiproDoxycycline
  • Any musculosketal side effect 14%
  • Any side effect 41%
  • Any musculoskeletal side effect 9%
  • Any neurological side effect 3%
  • Nausea 3%
  • Diarrhea 2%
  • Any gastrointestinal side effect 15%
  • Any serious side effect 8%
  • Vomiting 5%
  • Abdominal pain 3%
More Cipro side effects »
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
How it works
CiproDoxycycline
Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
CiproDoxycycline
Prescription only
Prescription only
Available as
CiproDoxycycline
  • Pill
  • Extended release
  • Infusion (iv)
  • Pill
  • Delayed release capsule
  • Liquid
Used for
CiproDoxycycline
Risk factors for serious side effects
CiproDoxycycline
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • Myasthenia gravis
        Detailed Cipro (ciprofloxacin) risks & warnings »
        • Age 8 years or younger
        • Using oral birth control pills
        • Long antibiotic treatment period
            • Women of childbearing age
            • Women of childbearing age
            • Overweight or obese
            • Taking isotretinoin (Accutane)
            Detailed Vibramycin (doxycycline) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Pain
            CiproDoxycycline
            • If you notice pain in your Achilles tendons, contact your doctor.
            • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
            • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
            No pain related info.
            Upsides and benefits
            CiproDoxycycline
            • Available in generic.
            • Available in different forms: tablet, capsule, and suspension.
            • Used to treat many types of bacterial infections.
            • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
            • Available in generic.
            • Available in different forms: tablet, capsule, and suspension.
            • Used to treat many types of bacterial infections.
            • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
            Downsides and risks
            CiproDoxycycline
            • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
            • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
            • Ciprofloxacin can make your skin more sensitive to the sun.
            • Can't be used if you've ever had myasthenia gravis.
            • Can cause diarrhea.
            • Can't be used in pregnant women and children under 8 years old.
            • Makes your skin more sensitive to the sun.
            • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
            • Can make birth control less effective.
            • Can cause diarrhea.
            Tips from our pharmacists for people taking the medication
            CiproDoxycycline
            • If you notice pain in your Achilles tendons, contact your doctor.
            • Wear sunscreen if you're going to be out in the sun.
            • Take the medication exactly how the doctor tells you to.
            • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
            • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
            • Can cause diarrhea, nausea or vomiting.
            • Limit your caffeine intake while taking this medication.
            • Take the medication exactly how your doctor tells you to.
            • If you're using birth control pills, this medication can make them less effective.
            • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
            • Can cause diarrhea, nausea or vomiting.
            • Space out any vitamins by at least two hours.
            • Take with plenty of food and liquids.
            • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
            • Don't lie down for at least 30 minutes after taking this medication.
            Learn more
            More about CiproSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Cipro (ciprofloxacin)?
            Worth itNot sureNot worth it
            More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Vibramycin (doxycycline)?
            Worth itNot sureNot worth it