Compare Cipro vs. Penicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cipro (ciprofloxacin)

Prescription only
Treats bacterial infections.

Cipro (ciprofloxacin) is a good, cheap antibiotic that treats many types of bacterial infections, but it interacts with some food and drugs.

3.8/ 5 average rating with 755 reviewsforCipro
Kills bacteria.

Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.

3.9/ 5 average rating with 1297 reviewsforPenicillin
Upsides
  • Cipro (ciprofloxacin) is available in generic.
  • Cipro (ciprofloxacin) comes in different forms, including intravenous (IV) injection.
  • Available in generic.
  • Available in different forms: tablet, capsule and suspension.
  • Used to treat many types of bacterial infections.
Downsides
  • Cipro (ciprofloxacin) should be used with caution if you have kidney problems.
  • If you drink caffeine while on Cipro (ciprofloxacin), you may notice increased effects of the caffeine.
  • Some bacteria have developed resistance to Cipro (ciprofloxacin).
  • Cipro (ciprofloxacin) can interact with many other medications. Tell your doctor and pharmacist what medications, over-the-counter products, and supplements you are taking before starting Cipro (ciprofloxacin).
  • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
  • Can make birth control pills less effective.
  • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Extended release pill
  • Pill
No pricing information available
No pricing information available
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Reviews
755 reviews so far
63%
saidit'sworth it
53%
saiditworked well
17%
saidit'sa big hassle

Have you used Cipro (ciprofloxacin)?

Leave a review
1297 reviews so far
71%
saidit'sworth it
52%
saiditworked well
12%
saidit'sa big hassle

Have you used Penicillin Vk (Penicillin)?

Leave a review
Side effects
2possible side effects
  • Nausea
    3%
  • Diarrhea
    2%
See more detailed side effects
The Penicillin Vk (Penicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tendon rupture
    • People over age 60
    • Taking steroid medicine
    • Those with kidney, heart, or lung transplants
  • Myasthenia gravis
    • Myasthenia gravis
  • Diarrhea
  • Nerve damage
  • Central nervous system effects
    • Central nervous system disorders
    • Seizures
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
See more detailed risks and warnings
  • Diarrhea
  • Decreased effectiveness of birth control pills
  • Allergic reactions
    • Prior severe allergic reaction to Penicillin Vk (Penicillin)
See more detailed risks and warnings