Compare Claritin-D vs. Advil Cold And Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin-D (loratadine / pseudoephedrine)

Prescription or OTC
Treats allergies and clears up nasal congestion.

Claritin-D (loratadine / pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness but it can keep you up at night.

5.0/ 7 average rating with 1527 reviewsforClaritin-D
Relieves sinus pain and congestion.

Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.

5.0/ 7 average rating with 1464 reviewsforAdvil Cold And Sinus
Upsides
  • This once-daily, single-pill combination conveniently treats congestion and other allergy symptoms.
  • It doesn't cause any daytime drowsiness unlike other antihistamines.
  • It doesn't require a prescription from your doctor.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
Downsides
  • The decongestant (pseudoephedrine) can make you anxious or your heart race. You may not sleep as well at night.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • It may interfere with how your other medicines work. Talk to your doctor or pharmacist before combining with other medicines.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
Used for
Dosage forms
  • Extended-release pill
  • Pill
No pricing information available
No pricing information available
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Reviews
1527 
69%
think this treatment is worth it
39%
think this treatment works well
8%
think this treatment is a hassle

Have you used Claritin-D (loratadine / pseudoephedrine)?

Leave a review
1464 
75%
think this treatment is worth it
34%
think this treatment works well
6%
think this treatment is a hassle

Have you used Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)?

Leave a review
Side effects
10possible side effects
  • Headache
    19%
  • Insomnia
    16%
  • Dry mouth
    14%
  • Drowin
    7%
  • Nervousness or anxiety
    5%
  • Dizziness
    4%
  • Indigestion
    3%
  • Nausea
    3%
  • Sore throat
    3%
  • Fatigue
    3%
See more detailed side effects
The Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Restlesness

    History of heart problems

    ...and 3 more risk factors

  • Difficulty concentrating

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Harm to fetus

    Women of childbearing age

  • High blood pressure

    History of high blood pressure

  • Lower kidney function

    Kidney disease

    ...and 4 more risk factors

  • Heart attack or stroke

    History of heart problems

    ...and 2 more risk factors

See more detailed risks and warnings