Compare Claritin D vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin D
(Loratadine / Pseudoephedrine)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Relieves congestion and allergy symptoms. Claritin D (Loratadine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.9571240105540895Claritin D
Reviews for Claritin D (Loratadine / Pseudoephedrine)
69%
of people say Claritin D (Loratadine / Pseudoephedrine) is worth it
38%
say it works well
8%
say it's a big hassle
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+14% vs. Claritin D (Loratadine / Pseudoephedrine)
42%
+4% vs. Claritin D (Loratadine / Pseudoephedrine)
6%
+2% vs. Claritin D (Loratadine / Pseudoephedrine)
Side effects
Claritin DNyquil Cold and Flu

We haven’t found good data for Claritin D side effects.

FDA side effect reports for Claritin D »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
Claritin DNyquil Cold and Flu
Claritin D (Loratadine / Pseudoephedrine) is a combination medicine for allergies. Loratadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Claritin DNyquil Cold and Flu
Antihistamine
2nd generation
DecongestantPrescription or OTC
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Available as
Claritin DNyquil Cold and Flu
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
Claritin DNyquil Cold and Flu
Risk factors for serious side effects
Claritin DNyquil Cold and Flu
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
    • Age 65 years or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of phenylketonuria (PKU)
    Detailed Claritin D (Loratadine / Pseudoephedrine) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • Using other medications that affect serotonin
    • Taking with alcohol
    • Taking with other medicines that make you less alert
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
    Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
    Pregnancy category
    Claritin DNyquil Cold and Flu
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Avoid using alcohol and other drugs that make you drowsy.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
    • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • People age 65 and older have a higher risk of troublesome side effects from taking antihistamine medications like Claritin D (Loratadine / Pseudoephedrine). Watch out for changes in vision, severe dry mouth, trouble urinating, or constipation. Also, feelings of drowsiness may leave you "unsteady" on your feet. This can make you more likely to fall causing broken bones or other serious injuries. Talk with your doctor before using Claritin D (Loratadine / Pseudoephedrine) and stop using it if you have side effects.
    • The antihistamine (doxylamine) will help you sleep.
    • Avoid using alcohol and other drugs that make you drowsy.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Claritin DNyquil Cold and Flu
    • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
    • The decongestant (Pseudoephedrine) in Claritin D (Loratadine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
    • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
    • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
    • It's available without a prescription, unlike other strong allergy medicines.
    • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
    • The cough medicine (dextromethorphan) works well and has very few side effects.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • The antihistamine (doxylamine) will help you sleep.
    Downsides and risks
    Claritin DNyquil Cold and Flu
    • You can have more side effects when using combination pills than when using single-ingredient medications.
    • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
    • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
    • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
    • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Tips from our pharmacists for people taking the medication
    Claritin DNyquil Cold and Flu
    • Starts working in 30 minutes.
    • You need to show an ID to buy Claritin D (Loratadine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
    • Don't cut, crush, or chew tablets; swallow them whole.
    • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
    • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Avoid using alcohol and other drugs that make you drowsy.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    Learn more
    More about Claritin DSide effectsReviews & ratingsAlternativesFDA package insert
    More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert