Compare Claritin D vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin D
(loratadine / pseudoephedrine)

Nyquil Cold And Flu
(acetaminophen / dextromethorphan / doxylamine)

Relieves congestion and allergy symptoms. Claritin D (Loratadine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
Reviews & ratings
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Filter group. All currently selected
4.97Claritin D
Reviews for Claritin D
69%
of people (All ages) say Claritin D is worth it
39%
say it works well
8%
say it's a big hassle
1527 reviews
Have you used Claritin D (loratadine / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Nyquil Cold And Flu
83%
-14% worse vs. Claritin D
42%
-3% worse vs. Claritin D
7%
-1% worse vs. Claritin D
1188 reviews
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it
Side effects
Claritin DNyquil Cold And Flu

We haven’t found good data for Claritin D side effects.

FDA side effect reports for Claritin D »

We haven’t found good data for Nyquil Cold And Flu side effects.

FDA side effect reports for Nyquil Cold And Flu »
How it works
Claritin DNyquil Cold And Flu
Claritin D (Loratadine / Pseudoephedrine) is a combination medicine for allergies. Loratadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Claritin DNyquil Cold And Flu
Prescription or OTCOver-the-counter
Available as
Claritin DNyquil Cold And Flu
  • Extended release
  • Pill
  • Liquid
Used for
Claritin DNyquil Cold And Flu
Risk factors for serious side effects
Claritin DNyquil Cold And Flu
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Claritin D (loratadine / pseudoephedrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
Detailed Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Claritin DNyquil Cold And Flu
No alcohol related info.
  • Avoid using alcohol and other drugs that make you drowsy.
Food
Claritin DNyquil Cold And Flu
  • Claritin D (Loratadine / Pseudoephedrine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
No food related info.
Kidneys and liver
Claritin DNyquil Cold And Flu
No kidneys and liver related info.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
Claritin DNyquil Cold And Flu
No pain related info.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Sleep
Claritin DNyquil Cold And Flu
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
No sleep related info.
Upsides and benefits
Claritin DNyquil Cold And Flu
  • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
  • The decongestant (Pseudoephedrine) in Claritin D (Loratadine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
Claritin DNyquil Cold And Flu
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Claritin DNyquil Cold And Flu
  • Starts working in 30 minutes.
  • You need to show an ID to buy Claritin D (Loratadine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
  • Don't cut, crush, or chew tablets; swallow them whole.
  • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Claritin DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Claritin D (loratadine / pseudoephedrine)?
Worth itNot sureNot worth it
More about Nyquil Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it