Compare Claritin-D vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats allergies and clears up nasal congestion.

Claritin-D (loratadine / pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness but it can keep you up at night.

3.6/ 5 average rating with 1527 reviewsforClaritin-D
Relieves cold and flu symptoms, and helps you sleep.

Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

3.8/ 5 average rating with 1188 reviewsforNyquil Cold And Flu
Upsides
  • This once-daily, single-pill combination conveniently treats congestion and other allergy symptoms.
  • It doesn't cause any daytime drowsiness unlike other antihistamines.
  • It doesn't require a prescription from your doctor.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides
  • The decongestant (pseudoephedrine) can make you anxious or your heart race. You may not sleep as well at night.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • It may interfere with how your other medicines work. Talk to your doctor or pharmacist before combining with other medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
  • Extended-release pill
  • Pill
  • Liquid
No pricing information available
No pricing information available
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Reviews
1527 reviews so far
69%
saidit'sworth it
39%
saiditworked well
8%
saidit'sa big hassle

Have you used Claritin-D (loratadine / pseudoephedrine)?

Leave a review
1188 reviews so far
83%
saidit'sworth it
42%
saiditworked well
7%
saidit'sa big hassle

Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?

Leave a review
Side effects
12possible side effects
  • Headache
    19%
  • Insomnia
    16%
  • Dry mouth
    14%
  • Drowin
    7%
  • Nervousness or anxiety
    5%
  • Dizziness
    4%
  • Indigestion
    3%
  • Nausea
    3%
  • Sore throat
    3%
  • Fatigue
    3%
  • Increased thirst
    2%
  • Loss of appetite
    2%
See more detailed side effects
The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • High blood pressure
    • History of high blood pressure
    • Glaucoma
  • Restlesness
    • History of heart problems
    • Overactive thyroid
    • Diabetes
    • Over age 65
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Driving impairment
    • Taking with alcohol
    • Taking with other medicines that make you less alert
  • Antihistamine side effects
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
See more detailed risks and warnings