Compare Claritin D vs. Zyrtec D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin D
(loratadine / pseudoephedrine)

Zyrtec D
(cetirizine / pseudoephedrine)

Relieves congestion and allergy symptoms. Claritin D (Loratadine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.Relieves congestion and allergy symptoms. Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Claritin D
Best available price for 60 (12 hour) tablets of loratadine / pseudoephedrine
Coupons for Zyrtec D
Best available price for 60 (12 hour) tablets of cetirizine / pseudoephedrine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.97Claritin D
Reviews for Claritin D (loratadine / pseudoephedrine)
69%
of people (All ages) say Claritin D (loratadine / pseudoephedrine) is worth it
39%
say it works well
8%
say it's a big hassle
1527 reviews
Have you used Claritin D (loratadine / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Zyrtec D (cetirizine / pseudoephedrine)
75%
+6% better vs. Claritin D (loratadine / pseudoephedrine)
43%
+4% better vs. Claritin D (loratadine / pseudoephedrine)
9%
-1% worse vs. Claritin D (loratadine / pseudoephedrine)
927 reviews
Have you used Zyrtec D (cetirizine / pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
Claritin DZyrtec D

We haven’t found good data for Claritin D side effects.

FDA side effect reports for Claritin D »

We haven’t found good data for Zyrtec D side effects.

FDA side effect reports for Zyrtec D »
How it works
Claritin DZyrtec D
Claritin D (Loratadine / Pseudoephedrine) is a combination medicine for allergies. Loratadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Zyrtec D (Cetirizine / Pseudoephedrine) is a combination medicine for allergies. Cetirizine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Claritin DZyrtec D
Prescription or OTC
Prescription or OTC
Available as
Claritin DZyrtec D
  • Extended release
  • Extended release
Used for
Claritin DZyrtec D
Risk factors for serious side effects
Claritin DZyrtec D
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Claritin D (loratadine / pseudoephedrine) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Zyrtec D (cetirizine / pseudoephedrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
Claritin DZyrtec D
  • Claritin D (Loratadine / Pseudoephedrine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
No food related info.
Kidneys and liver
Claritin DZyrtec D
No kidneys and liver related info.
  • People with kidney or liver disease may need to take a lower dose of Zyrtec D (Cetirizine / Pseudoephedrine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
Sleep
Claritin DZyrtec D
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
Upsides and benefits
Claritin DZyrtec D
  • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
  • The decongestant (Pseudoephedrine) in Claritin D (Loratadine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
Downsides and risks
Claritin DZyrtec D
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
Tips from our pharmacists for people taking the medication
Claritin DZyrtec D
  • Starts working in 30 minutes.
  • You need to show an ID to buy Claritin D (Loratadine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
  • Don't cut, crush, or chew tablets; swallow them whole.
  • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
  • Starts working in 30 minutes.
  • You need to show an ID to buy Zyrtec D (Cetirizine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
  • Don't cut, crush, or chew tablets; swallow them whole.
  • It's better to take Zyrtec D (Cetirizine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
Learn more
More about Claritin DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Claritin D (loratadine / pseudoephedrine)?
Worth itNot sureNot worth it
More about Zyrtec DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyrtec D (cetirizine / pseudoephedrine)?
Worth itNot sureNot worth it