Compare Claritin vs. Advil Allergy and Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin
(Loratadine)

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Treats allergy symptoms. Claritin (Loratadine) is a once-daily allergy relief medication that doesn't make you feel sleepy.Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5Claritin
Reviews for Claritin (Loratadine)
74%
of people say Claritin (Loratadine) is worth it
38%
say it works well
6%
say it's a big hassle
Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
1% vs. Claritin (Loratadine)
30%
8% vs. Claritin (Loratadine)
6%
Same vs. Claritin (Loratadine)
Side effects
ClaritinAdvil Allergy and Congestion Relief

We haven’t found good data for Claritin side effects.

FDA side effect reports for Claritin »

We haven’t found good data for Advil Allergy and Congestion Relief side effects.

FDA side effect reports for Advil Allergy and Congestion Relief »
How it works
ClaritinAdvil Allergy and Congestion Relief
Claritin (Loratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Loratadine is a low-drowsiness version.Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
ClaritinAdvil Allergy and Congestion Relief
Antihistamine
2nd generation
Prescription or OTC
Antihistamine
1st generation
Pain reliever
NSAID
DecongestantOver-the-counter
Available as
ClaritinAdvil Allergy and Congestion Relief
  • Pill
  • Chewable tablet
  • Orally disintegrating tablet
  • Liquid
  • Pill
Used for (click to learn more)
ClaritinAdvil Allergy and Congestion Relief
Risk factors for serious side effects
ClaritinAdvil Allergy and Congestion Relief
    • Age 65 or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of phenylketonuria (PKU)
    Detailed Claritin (Loratadine) risks & warnings »
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Women of childbearing age
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
    • Taking with aspirin
    Detailed Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) risks & warnings »
    Pregnancy category
    ClaritinAdvil Allergy and Congestion Relief
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) for any amount of time.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
    • People age 65 and older have a higher risk of troublesome side effects from taking antihistamine medications like Claritin (Loratadine). Watch out for changes in vision, severe dry mouth, trouble urinating, or constipation. Also, feelings of drowsiness may leave you "unsteady" on your feet. This can make you more likely to fall causing broken bones or other serious injuries. Talk with your doctor before using Claritin (Loratadine) and stop using it if you have side effects.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    ClaritinAdvil Allergy and Congestion Relief
    • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
    • Also treats hives and itchy skin.
    • Side effects are rare and usually mild.
    • Available over the counter without a prescription.
    • Comes as a tablet, liquid, or quick-dissolving tablet.
    • Can provide quick relief of allergy symptoms for both kids and adults.
    • Okay to take with most other medications because it doesn't have many interactions.
    • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    Downsides and risks
    ClaritinAdvil Allergy and Congestion Relief
    • For some people, its effectiveness on treating allergies wears off over time.
    • Some people find that other more sedating antihistamines (like Zyrtec or Benadryl) are more effective for them.
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    • Not for kids under 2 years.
    • The Reditabs version contains aspartame (phenylalanine).
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
    • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
    Tips from our pharmacists for people taking the medication
    ClaritinAdvil Allergy and Congestion Relief
    • Take it only once a day.
    • Starts working in a few hours.
    • Can make you feel sleepy, so take it at bedtime if needed.
    • Avoid possible side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead, which might work better for you long-term.
    • Using an antihistamine eye drop might work better to help itchy or watery eyes.
    • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
    • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
    • While taking this, avoid alcohol and other drugs that make you drowsy.
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Don't use in kids age 12 years or younger.
    Learn more
    More about ClaritinSide effectsReviews & ratingsAlternativesFDA package insert
    More about Advil Allergy and Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert