Compare Claritin vs. Allegra D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin
(loratadine)

Allegra D
(pseudoephedrine / fexofenadine)

Treats allergy symptoms. Claritin (Loratadine) is a once-daily allergy relief medication that doesn't make you feel sleepy.Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.
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Reviews & ratings
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5Claritin
Reviews for Claritin (loratadine)
74%
of people (All ages) say Claritin (loratadine) is worth it
38%
say it works well
6%
say it's a big hassle
1517 reviews
Have you used Claritin (loratadine)?
Worth itNot sureNot worth it

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Have you used Allegra D (pseudoephedrine / fexofenadine)?
Worth itNot sureNot worth it
Side effects
ClaritinAllegra D

We haven’t found good data for Claritin side effects.

FDA side effect reports for Claritin »
  • Headache 3%
  • Back pain 2%
  • Sleep difficulty 13%
  • Nausea 7%
  • Adverse effects 4%
  • Indigestion 3%
  • Dry mouth 3%
  • Dizziness 2%
  • Agitation 2%
More Allegra D side effects »
How it works
ClaritinAllegra D
Claritin (Loratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Loratadine is a low-drowsiness version.Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
ClaritinAllegra D
Prescription or OTC
Prescription or OTC
Available as
ClaritinAllegra D
  • Pill
  • Chewable tablet
  • Orally disintegrating tablet
  • Liquid
  • Extended release
Used for
ClaritinAllegra D
Risk factors for serious side effects
ClaritinAllegra D
    • Age 65 or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of phenylketonuria (PKU)
    Detailed Claritin (loratadine) risks & warnings »
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of high blood pressure
    • History of heart problems
    • Age 65 or older
    • History of seizure
    • Women of childbearing age
    Detailed Allegra D (pseudoephedrine / fexofenadine) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    ClaritinAllegra D
    • Claritin (Loratadine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
    No food related info.
    Sleep
    ClaritinAllegra D
    • Can make you feel sleepy, so take it at bedtime if needed.
    • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
    Upsides and benefits
    ClaritinAllegra D
    • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
    • Also treats hives and itchy skin.
    • Side effects are rare and usually mild.
    • Available over the counter without a prescription.
    • Comes as a tablet, liquid, or quick-dissolving tablet.
    • Can provide quick relief of allergy symptoms for both kids and adults.
    • Okay to take with most other medications because it doesn't have many interactions.
    • Available without a prescription in the drugstore.
    • It has two medications that work in different ways to help relieve nasal symptoms.
    • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
    • The decongestant (pseudoephedrine) is very good at relieving congestion.
    Downsides and risks
    ClaritinAllegra D
    • For some people, its effectiveness on treating allergies wears off over time.
    • Some people find that other more sedating antihistamines (like Zyrtec or Benadryl) are more effective for them.
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    • Not for kids under 2 years.
    • The Reditabs version contains aspartame (phenylalanine).
    • Has more side effects than Allegra since it has pseudoephedrine in it.
    • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
    • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
    • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
    Tips from our pharmacists for people taking the medication
    ClaritinAllegra D
    • Take it only once a day.
    • Starts working in a few hours.
    • Can make you feel sleepy, so take it at bedtime if needed.
    • Avoid possible side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead, which might work better for you long-term.
    • Using an antihistamine eye drop might work better to help itchy or watery eyes.
    • It works best if you have nasal congestion and a runny nose.
    • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
    • Shouldn't be used in kids younger than 12 years old.
    • Avoid taking it close to bedtime to prevent trouble sleeping.
    • Can cause dizziness, headache, or a fast heartbeat.
    • Talk to your doctor if you have high blood pressure or kidney problems before using it.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    Learn more
    More about ClaritinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Claritin (loratadine)?
    Worth itNot sureNot worth it
    More about Allegra DSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Allegra D (pseudoephedrine / fexofenadine)?
    Worth itNot sureNot worth it