Compare Claritin vs. Claritin D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Claritin
(loratadine)

Claritin D
(loratadine / pseudoephedrine)

Treats allergy symptoms. Claritin (Loratadine) is a once-daily allergy relief medication that doesn't make you feel sleepy.Relieves congestion and allergy symptoms. Claritin D (Loratadine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.
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Coupons for Claritin
Best available price for 30 (24 hour) tablets of claritin
Coupons for Claritin D
Best available price for 60 (12 hour) tablets of claritin-d
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5Claritin
Reviews for Claritin
74%
of people (All ages) say Claritin is worth it
38%
say it works well
6%
say it's a big hassle
1517 reviews
Have you used Claritin (loratadine)?
Worth itNot sureNot worth it
Reviews for Claritin D
69%
+5% better vs. Claritin
39%
-1% worse vs. Claritin
8%
+2% better vs. Claritin
1527 reviews
Have you used Claritin D (loratadine / pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
ClaritinClaritin D

We haven’t found good data for Claritin side effects.

FDA side effect reports for Claritin »

We haven’t found good data for Claritin D side effects.

FDA side effect reports for Claritin D »
How it works
ClaritinClaritin D
Claritin (Loratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Loratadine is a low-drowsiness version.Claritin D (Loratadine / Pseudoephedrine) is a combination medicine for allergies. Loratadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
ClaritinClaritin D
Prescription or OTCPrescription or OTC
Available as
ClaritinClaritin D
  • Pill
  • Chewable tablet
  • Orally disintegrating tablet
  • Liquid
  • Extended release
Used for
ClaritinClaritin D
Risk factors for serious side effects
ClaritinClaritin D
  • Age 65 or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Claritin (loratadine) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Claritin D (loratadine / pseudoephedrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
ClaritinClaritin D
  • Claritin (Loratadine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
  • Claritin D (Loratadine / Pseudoephedrine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
Sleep
ClaritinClaritin D
  • Can make you feel sleepy, so take it at bedtime if needed.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
Upsides and benefits
ClaritinClaritin D
  • Relieves allergy symptoms like sneezing and runny nose just as well as other antihistamines, but with less sedation (drowsiness).
  • Also treats hives and itchy skin.
  • Side effects are rare and usually mild.
  • Available over the counter without a prescription.
  • Comes as a tablet, liquid, or quick-dissolving tablet.
  • Can provide quick relief of allergy symptoms for both kids and adults.
  • Okay to take with most other medications because it doesn't have many interactions.
  • The antihistamine (Loratadine) in Claritin D (Loratadine / Pseudoephedrine) works as well as other antihistamines, but causes less drowsiness. It's also less sedating than Allegra D and Zyrtec D.
  • The decongestant (Pseudoephedrine) in Claritin D (Loratadine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
Downsides and risks
ClaritinClaritin D
  • For some people, its effectiveness on treating allergies wears off over time.
  • Some people find that other more sedating antihistamines (like Zyrtec or Benadryl) are more effective for them.
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
  • Not for kids under 2 years.
  • The Reditabs version contains aspartame (phenylalanine).
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
Tips from our pharmacists for people taking the medication
ClaritinClaritin D
  • Take it only once a day.
  • Starts working in a few hours.
  • Can make you feel sleepy, so take it at bedtime if needed.
  • Avoid possible side effects by drinking plenty of non-caffeinated liquids.
  • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead, which might work better for you long-term.
  • Using an antihistamine eye drop might work better to help itchy or watery eyes.
  • Starts working in 30 minutes.
  • You need to show an ID to buy Claritin D (Loratadine / Pseudoephedrine) in the drugstore because it contains Pseudoephedrine.
  • Don't cut, crush, or chew tablets; swallow them whole.
  • It's better to take Claritin D (Loratadine / Pseudoephedrine) early in the morning or when you wake up, otherwise you can have trouble sleeping later.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • If you need to use it for more than a few weeks, talk with your doctor since a different medication might work better for you.
Learn more
More about ClaritinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Claritin (loratadine)?
Worth itNot sureNot worth it
More about Claritin DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Claritin D (loratadine / pseudoephedrine)?
Worth itNot sureNot worth it