Compare Cleocin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cleocin T
(clindamycin phosphate)

Bactrim
(sulfamethoxazole / trimethoprim)

Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.
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Reviews & ratings
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4.79Cleocin
Reviews for Cleocin T (clindamycin phosphate)
57%
of people (All ages) say Cleocin T (clindamycin phosphate) is worth it
43%
say it works well
19%
say it's a big hassle
115 reviews
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
Reviews for Bactrim (sulfamethoxazole / trimethoprim)
59%
+2% better vs. Cleocin T (clindamycin phosphate)
49%
+6% better vs. Cleocin T (clindamycin phosphate)
22%
-3% worse vs. Cleocin T (clindamycin phosphate)
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Side effects
CleocinBactrim
  • Any side effect 21%
  • Vaginal moniliasis 8%
  • Vulvovaginitis 6%
  • Vulvovaginal disorder 3%
  • Moniliasis (body) 2%
  • Fungal infection 2%
More Cleocin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
CleocinBactrim
Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.
Type of medication
CleocinBactrim
Prescription only
Prescription only
Available as
CleocinBactrim
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Pill
  • Liquid
Used for
CleocinBactrim
Risk factors for serious side effects
CleocinBactrim
    • History of liver disease
      Detailed Cleocin T (clindamycin phosphate) risks & warnings »
              • Elderly
              • Taking other medicines that lower kidney function
              Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
              Pregnancy

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Food
              CleocinBactrim
              • Can be taken with or without food.
              No food related info.
              Kidneys and liver
              CleocinBactrim
              • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
              • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
              Pain
              CleocinBactrim
              • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
              No pain related info.
              Upsides and benefits
              CleocinBactrim
              • Available in generic.
              • Topical form treats acne.
              • Available in different oral forms: tablet, capsule, and suspension.
              • Available in forms to treat skin infections and vaginal infections.
              • Used to treat many types of bacterial infections.
              • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
              • Can be taken with or without food.
              • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
              • Works well to treat many types of bacterial infections
              Downsides and risks
              CleocinBactrim
              • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
              • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
              • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
              • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
              • If you're taking the topical form, it can cause sensitivity and irritation.
              • Makes you sensitive to the sun.
              • Can upset your stomach
              • Drink plenty of water or fluids to avoid harming your kidneys
              • May cause birth defects
              Tips from our pharmacists for people taking the medication
              CleocinBactrim
              • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
              • Take this medication exactly how your doctor tells you to.
              • Store the suspension at room temperature.
              • If you're using the topical form, it can take a few weeks to see the full effect.
              • Keep the topical form out of your eyes, nose and mouth.
              • If you're using the topical form, Don't put makeup or bandages over it.
              • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
              • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
              • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
              • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
              • Can cause upset stomach.
              • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
              Learn more
              More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Cleocin T (clindamycin phosphate)?
              Worth itNot sureNot worth it
              More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Bactrim (sulfamethoxazole / trimethoprim)?
              Worth itNot sureNot worth it