Compare Cleocin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cleocin T
(Clindamycin Phosphate)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.794642857142857Cleocin
Reviews for Cleocin T (Clindamycin Phosphate)
57%
of people say Cleocin T (Clindamycin Phosphate) is worth it
43%
say it works well
20%
say it's a big hassle
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
+2% vs. Cleocin T (Clindamycin Phosphate)
50%
+7% vs. Cleocin T (Clindamycin Phosphate)
22%
2% vs. Cleocin T (Clindamycin Phosphate)
Side effects
CleocinBactrim
  • Vaginal moniliasis 6%
More Cleocin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
CleocinBactrim
Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.
Type of medication
CleocinBactrim
Acne agent
Antibiotic
Prescription only
Antibiotic
Sulfonamide
Prescription only
Available as
CleocinBactrim
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Pill
  • Liquid
Used for (click to learn more)
CleocinBactrim
Risk factors for serious side effects
CleocinBactrim
    • History of liver disease
      Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
              Detailed Bactrim (Sulfamethoxazole / Trimethoprim) risks & warnings »
              Pregnancy category
              CleocinBactrim
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
              • Can be taken with or without food.
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
              • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
              No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              CleocinBactrim
              • Topical form treats acne.
              • Available in different oral forms: tablet, capsule, and suspension.
              • Available in forms to treat skin infections and vaginal infections.
              • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
              • Can be taken with or without food.
              • Available in generic.
              • Used to treat many types of bacterial infections.
              • Available in different forms: tablet, capsule and suspension.
              • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
              • Available in generic.
              • Used to treat many types of bacterial infections.
              Downsides and risks
              CleocinBactrim
              • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
              • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
              • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
              • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
              • If you're taking the topical form, it can cause sensitivity and irritation.
              • Makes your skin more sensitive to the sun.
              • Has to be taken with plenty of liquids.
              • May cause birth defects.
              • Can cause diarrhea.
              Tips from our pharmacists for people taking the medication
              CleocinBactrim
              • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
              • Store the suspension at room temperature.
              • If you're using the topical form, it can take a few weeks to see the full effect.
              • Keep the topical form out of your eyes, nose and mouth.
              • If you're using the topical form, Don't put makeup or bandages over it.
              • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
              • Take this medication exactly how your doctor tells you to.
              • Can make your skin more sensitive to the sun.
              • Drink plenty of liquids when taking the medication.
              • Can cause diarrhea, nausea or vomiting.
              • Can cause rash.
              • Take this medication exactly how your doctor tells you to.
              Learn more
              More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
              More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert