Compare Cleocin vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cleocin T
(Clindamycin Phosphate)

Akne-Mycin
(Erythromycin)

Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.794642857142857Cleocin
Reviews for Cleocin T (Clindamycin Phosphate)
57%
of people say Cleocin T (Clindamycin Phosphate) is worth it
43%
say it works well
20%
say it's a big hassle
Reviews for Akne-Mycin (Erythromycin)
46%
11% vs. Cleocin T (Clindamycin Phosphate)
34%
9% vs. Cleocin T (Clindamycin Phosphate)
20%
Same vs. Cleocin T (Clindamycin Phosphate)
Side effects
CleocinErygel
  • Vaginal moniliasis 6%
More Cleocin side effects »

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »
How it works
CleocinErygel
Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
CleocinErygel
Acne agent
Antibiotic
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
CleocinErygel
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Cream, gel, or ointment
  • Topical solution
Used for (click to learn more)
CleocinErygel
Risk factors for serious side effects
CleocinErygel
    • History of liver disease
      Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
        • Using other medicines or products that irritate the skin
        • Eczema
        • Extreme temperatures (hot or cold)
          Detailed Akne-Mycin (Erythromycin) risks & warnings »
          Pregnancy category
          CleocinErygel
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • Can be taken with or without food.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          CleocinErygel
          • Available in generic.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
          • Available in a gel formulation which may be better if your skin is very oily.
          • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
          Downsides and risks
          CleocinErygel
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
          • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
          Tips from our pharmacists for people taking the medication
          CleocinErygel
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          • Very commonly used topical antibiotic to treat acne.
          • The only topical erythromycin in a gel formula.
          • Apply a thin film to clean and dry affected skin once or twice a day.
          • It may take 6-8 weeks before you see improvement in your acne.
          • Avoid getting into your eyes, nose or mouth.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          Learn more
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
          More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert