Compare Cleocin vs. Renova

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cleocin T
(Clindamycin Phosphate)

Renova
(Tretinoin)

Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.794642857142857Cleocin
Reviews for Cleocin T (Clindamycin Phosphate)
57%
of people say Cleocin T (Clindamycin Phosphate) is worth it
43%
say it works well
20%
say it's a big hassle
Reviews for Renova (Tretinoin)
40%
17% vs. Cleocin T (Clindamycin Phosphate)
26%
17% vs. Cleocin T (Clindamycin Phosphate)
28%
8% vs. Cleocin T (Clindamycin Phosphate)
Side effects
CleocinRenova
  • Vaginal moniliasis 6%
More Cleocin side effects »
  • Severe local irritation 6%
More Renova side effects »
How it works
CleocinRenova
Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.
Type of medication
CleocinRenova
Acne agent
Antibiotic
Prescription only
Acne agent
Retinoid
Prescription only
Available as
CleocinRenova
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Cream, gel, or ointment
Used for (click to learn more)
CleocinRenova
Risk factors for serious side effects
CleocinRenova
    • History of liver disease
      Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
      • Using other medicines or products that irritate the skin
      • Eczema
      • Extreme temperatures (hot or cold)
        • Allergy to fish or fish products
          Detailed Renova (Tretinoin) risks & warnings »
          Pregnancy category
          CleocinRenova
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • Can be taken with or without food.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          CleocinRenova
          • Available in generic.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          • You only need to apply it once a day, usually in the evening.
          • Most people who reported having skin irritation said that it was mild.
          • Part of a complete program to help you take better care of your skin.
          Downsides and risks
          CleocinRenova
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          • It may take up to 6 months to see the full benefit for facial wrinkles.
          • Not a good choice for women who want to become or are pregnant
          • Can change the color and texture of your skin if used long-term.
          • You need to be careful about avoiding any sunlight or artificial tanning while using it.
          • It doesn't work for deep wrinkles.
          Tips from our pharmacists for people taking the medication
          CleocinRenova
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
          • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
          • Apply a very small amount (pea-size) on entire face once a day at bedtime.
          • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
          • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
          • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
          • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
          Learn more
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
          More about RenovaSide effectsReviews & ratingsFDA package insert