Compare Cleocin vs. Renova

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cleocin T
(clindamycin phosphate)

Renova
(tretinoin)

Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.
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Coupons for Cleocin
Best available price for 30 (30g of 1%) tube of gels of clindamycin
Coupons for Renova
Best available price for 40 (40g of 0.05%) tube of creams of renova
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79Cleocin
Reviews for Cleocin
57%
of people (All ages) say Cleocin is worth it
43%
say it works well
19%
say it's a big hassle
115 reviews
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
Reviews for Renova
41%
+16% better vs. Cleocin
28%
+15% better vs. Cleocin
28%
+9% better vs. Cleocin
Have you used Renova (tretinoin)?
Worth itNot sureNot worth it
Side effects
CleocinRenova
  • Any side effect 21%
  • Vaginal moniliasis 8%
  • Vulvovaginitis 6%
  • Vulvovaginal disorder 3%
  • Moniliasis (body) 2%
  • Fungal infection 2%
More Cleocin side effects »
  • Mild skin reactions 100%
  • Severe local irritation 6%
  • Any side effect 4%
  • Skin hypo- or hyperpigmentation 2%
More Renova side effects »
How it works
CleocinRenova
Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.
Type of medication
CleocinRenova
Prescription onlyPrescription only
Available as
CleocinRenova
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Cream, gel, or ointment
Used for
CleocinRenova
Risk factors for serious side effects
CleocinRenova
  • History of liver disease
Detailed Cleocin T (clindamycin phosphate) risks & warnings »
  • Using other medicines or products that irritate the skin
  • Eczema
  • Extreme temperatures (hot or cold)
  • Allergy to fish or fish products
Detailed Renova (tretinoin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CleocinRenova
  • Can be taken with or without food.
No food related info.
Kidneys and liver
CleocinRenova
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
No kidneys and liver related info.
Pain
CleocinRenova
  • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
No pain related info.
Upsides and benefits
CleocinRenova
  • Available in generic.
  • Topical form treats acne.
  • Available in different oral forms: tablet, capsule, and suspension.
  • Available in forms to treat skin infections and vaginal infections.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
  • You only need to apply it once a day, usually in the evening.
  • Most people who reported having skin irritation said that it was mild.
  • Part of a complete program to help you take better care of your skin.
Downsides and risks
CleocinRenova
  • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
  • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
  • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
  • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
  • If you're taking the topical form, it can cause sensitivity and irritation.
  • It may take up to 6 months to see the full benefit for facial wrinkles.
  • Not a good choice for women who want to become or are pregnant
  • Can change the color and texture of your skin if used long-term.
  • You need to be careful about avoiding any sunlight or artificial tanning while using it.
  • It doesn't work for deep wrinkles.
Tips from our pharmacists for people taking the medication
CleocinRenova
  • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
  • Take this medication exactly how your doctor tells you to.
  • Store the suspension at room temperature.
  • If you're using the topical form, it can take a few weeks to see the full effect.
  • Keep the topical form out of your eyes, nose and mouth.
  • If you're using the topical form, Don't put makeup or bandages over it.
  • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
  • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
  • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
  • Apply a very small amount (pea-size) on entire face once a day at bedtime.
  • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
  • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
  • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
  • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
Learn more
More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
More about RenovaSide effectsReviews & ratingsFDA package insert
Have you used Renova (tretinoin)?
Worth itNot sureNot worth it