Compare Climara vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Climara
(estradiol patch)

Combipatch
(estradiol / norethindrone patch)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.Treats low estrogen and relieves menopause symptoms. Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.
Reviews & ratings
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Have you used Climara (estradiol patch)?
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Have you used Combipatch (estradiol / norethindrone patch)?
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Side effects
ClimaraCombipatch
  • Breast pain 1%
  • Sinus infection 1%
  • Stuffy nose 1%
  • Swelling of arms and legs 7%
  • Stomach pain 3%
  • Pain 1%
More Climara side effects »
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu like symptoms 2%
  • Abnormal pap smear 3%
  • Weakness 4%
  • Stomach pain 3%
More Combipatch side effects »
How it works
ClimaraCombipatch
The Climara (estradiol patch) replaces estrogen that your body loses during and after menopause. Higher levels of estrogen help relieve symptoms of menopause and prevent bone loss.Combipatch (estradiol / norethindrone patch) is a combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
ClimaraCombipatch
Prescription onlyPrescription only
Available as
ClimaraCombipatch
  • Patch
  • Patch
Used for
ClimaraCombipatch
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
ClimaraCombipatch
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Climara (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
ClimaraCombipatch
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
No weight related info.
Upsides and benefits
ClimaraCombipatch
  • Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Climara (estradiol patch) is available as a generic product, which lowers the cost.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
Downsides and risks
ClimaraCombipatch
  • The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
  • If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
ClimaraCombipatch
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for at least 10 seconds, especially around the edges.
  • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly as directed by the manufacturer. Press the patch firmly in place for 10 seconds, especially around the edges. Don't place it at your waistline or on your breasts.
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to help prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Combipatch (estradiol / norethindrone patch) is not intended to be used forever. Talk to your doctor regularly to see if you still need treatment.
Learn more
More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it