Compare Climara vs. Divigel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Climara
(Estradiol Patch)

Divigel
(Estradiol Gel)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. You only have to think about the Climara (Estradiol Patch) once a week, and it may have fewer side effects than oral estrogen pills.Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.
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Side effects
ClimaraDivigel
  • Breast pain 25%
  • Ear, nose, or throat infection 9%
  • Abdominal pain 8%
  • Headache 8%
  • Swelling due to excess fluid 7%
  • Thick vaginal discharge 6%
  • Passing gas 6%
  • Inflammation inside the nose 5%
  • Sore throat 4%
  • Pain 4%
More Climara side effects »
  • Metrorrhagia 8%
  • Breast tenderness 7%
  • Ear, nose, or throat infection 4%
  • Vaginal mycosis 3%
  • Common cold 2%
More Divigel side effects »
How it works
ClimaraDivigel
The Climara (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
ClimaraDivigel
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
ClimaraDivigel
  • Patch
  • Cream, gel, or ointment
Used for (click to learn more)
ClimaraDivigel
  • Hot flashes and night sweats
  • Hot flashes and night sweats
Risk factors for serious side effects
ClimaraDivigel
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
  • High levels of triglycerides
Detailed Climara (Estradiol Patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
    Detailed Divigel (Estradiol Gel) risks & warnings »
    Pregnancy category
    ClimaraDivigel
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    ClimaraDivigel
    • The Climara (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • The patch is good for people who don't want to take daily pills.
    • Can be worn while swimming, bathing, and showering.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
    • Good for people who don't want to take daily pills.
    • The pre-measured packets are easy to use and can be taken anywhere.
    • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
    • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
    • Divigel (Estradiol Gel) is available in 3 strengths.
    • Very few women (less than 1%) had skin irritation from the medicine.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Downsides and risks
    ClimaraDivigel
    • Patch can fall off.
    • Increases your risk of uterine and breast cancer.
    • If you have your uterus, you have to use the Climara (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    Tips from our pharmacists for people taking the medication
    ClimaraDivigel
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
    • Replace the patch every 7 days on a different area of your skin to lower your risk of skin irritation.
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
    • Wash your hands well after applying the gel.
    • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Learn more
    More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
    More about DivigelSide effectsReviews & ratingsAlternativesFDA package insert