Compare Climara vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Climara
(estradiol patch)

Estring
(estradiol vaginal ring)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.
Reviews & ratings
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Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
Reviews for Estring
63%
+37% better vs. Climara
39%
+28% better vs. Climara
18%
+18% better vs. Climara
Have you used Estring (estradiol vaginal ring)?
Worth itNot sureNot worth it
Side effects
ClimaraEstring
  • Breast pain 1%
  • Sinus infection 1%
  • Stuffy nose 1%
  • Swelling of arms and legs 7%
  • Stomach pain 3%
  • Pain 1%
More Climara side effects »
  • Headache 13%
  • Thick vaginal discharge 7%
  • Back pain 6%
  • Yeast infection 6%
  • Ear, nose, or throat infection 5%
  • Vaginitis 5%
  • Vaginal discomfort/pain 5%
  • Sinus inflammation 4%
  • Asymptomatic genital bacterial growth 4%
  • Abdominal pain 4%
More Estring side effects »
How it works
ClimaraEstring
The Climara (estradiol patch) replaces estrogen that your body loses during and after menopause. Higher levels of estrogen help relieve symptoms of menopause and prevent bone loss.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.
Type of medication
ClimaraEstring
Prescription onlyPrescription only
Available as
ClimaraEstring
  • Patch
  • Vaginal ring
Used for
ClimaraEstring
  • Hot Flashes And Night Sweats
  • Vaginal Dryness And Inflammation
Risk factors for serious side effects
ClimaraEstring
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Climara (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Estring (estradiol vaginal ring) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
ClimaraEstring
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
No weight related info.
Upsides and benefits
ClimaraEstring
  • Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Climara (estradiol patch) is available as a generic product, which lowers the cost.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
Downsides and risks
ClimaraEstring
  • The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
  • If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
ClimaraEstring
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for at least 10 seconds, especially around the edges.
  • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
  • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
  • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
  • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
  • It can take up to 2 to 3 weeks to feel the full benefits.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.
Learn more
More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
More about EstringSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Estring (estradiol vaginal ring)?
Worth itNot sureNot worth it