Compare Climara vs. Minivelle

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Climara
(estradiol patch)

Minivelle
(estradiol patch)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.Relieves hot flashes due to menopause and lowers your risk of osteoporosis. The Minivelle (Estradiol Patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.
Reviews & ratings
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Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
Reviews for Minivelle
82%
+18% better vs. Climara
76%
-9% worse vs. Climara
18%
+18% better vs. Climara
Have you used Minivelle (estradiol patch)?
Worth itNot sureNot worth it
Side effects
ClimaraMinivelle
  • Breast pain 1%
  • Sinus infection 1%
  • Stuffy nose 1%
  • Swelling of arms and legs 7%
  • Stomach pain 3%
  • Pain 1%
More Climara side effects »
  • Breast tenderness 17%
  • Depression 7%
  • Back pain 3%
  • Weight increased 7%
  • Dyspepsia 3%
More Minivelle side effects »
How it works
ClimaraMinivelle
The Climara (estradiol patch) replaces estrogen that your body loses during and after menopause. Higher levels of estrogen help relieve symptoms of menopause and prevent bone loss.The Minivelle (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
ClimaraMinivelle
Prescription onlyPrescription only
Available as
ClimaraMinivelle
  • Patch
  • Patch
Used for
ClimaraMinivelle
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
ClimaraMinivelle
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Climara (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Minivelle (estradiol patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
ClimaraMinivelle
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
ClimaraMinivelle
  • Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Climara (estradiol patch) is available as a generic product, which lowers the cost.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • The [name_comon] is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • You’ll need to replace it twice a week, every 3 to 4 days.
  • Causes little or no skin irritation and doesn't leave adhesive on your skin.
  • The Minivelle (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
ClimaraMinivelle
  • The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
  • If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
  • You need to replace the Minivelle (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Minivelle (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Tips from our pharmacists for people taking the medication
ClimaraMinivelle
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for at least 10 seconds, especially around the edges.
  • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
More about MinivelleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Minivelle (estradiol patch)?
Worth itNot sureNot worth it