Compare Clozaril vs. Geodon

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Clozaril
(clozapine)

Geodon
(ziprasidone)

Helps control your thoughts and actions. Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.
Reviews & ratings
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Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it
Reviews for Geodon
43%
+14% better vs. Clozaril
43%
+28% better vs. Clozaril
30%
-27% worse vs. Clozaril
Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it
Side effects
ClozarilGeodon
  • Drowsiness/sedation 39%
  • Salivation 31%
  • Abnormally fast heart beat 25%
  • Dizziness/vertigo 19%
  • Constipation 14%
  • Low blood pressure 9%
  • Headache 7%
  • Dry mouth 6%
  • Sweating 6%
  • Fainting 6%
More Clozaril side effects »
  • Extrapyramidal symptoms 6%
  • Drowsiness 7%
  • Nausea 3%
  • Constipation 1%
  • Respiratory tract infection 5%
  • Dizziness 2%
  • Indigestion 1%
  • Restlessness 1%
  • Muscle weakness 2%
  • Diarrhea 1%
More Geodon side effects »
How it works
ClozarilGeodon
Clozaril (Clozapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
ClozarilGeodon
Prescription onlyPrescription only
Available as
ClozarilGeodon
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Injection
Used for
ClozarilGeodon
Risk factors for serious side effects
ClozarilGeodon
  • Dehydration
  • Taking blood pressure medications
  • Seizure disorder
  • Alcohol abuse
  • History of heart problems
Detailed Clozaril (clozapine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • Low potassium
  • Low magnesium
Detailed Geodon (ziprasidone) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ClozarilGeodon
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
No alcohol related info.
Sleep
ClozarilGeodon
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
Weight
ClozarilGeodon
  • People on Clozaril (Clozapine) have reported weight gain. This is common. If this bothers you, talk to your doctor about what you can do to stop this from happening.
  • Can affect your weight, cholesterol, and blood sugar control.
  • It causes slightly less weight gain than similar medicines.
Upsides and benefits
ClozarilGeodon
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
  • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
  • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
  • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
  • The Geodon (Ziprasidone) capsule is available as a generic.
  • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
  • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
Downsides and risks
ClozarilGeodon
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
  • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
  • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
  • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
  • It causes slightly less weight gain than similar medicines.
  • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
Tips from our pharmacists for people taking the medication
ClozarilGeodon
  • Take Clozaril (Clozapine) exactly as prescribed and don't stop taking it without talking to your doctor.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Blood tests are needed before you start this medicine and before every refill. You need to pick up the medicine within 7 days of your blood tests.
  • Can affect your weight, cholesterol, and blood sugar control.
  • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
  • Take Geodon (Ziprasidone) twice a day, preferably with food.
  • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
  • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
  • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
Learn more
More about ClozarilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it
More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it