Compare Clozaril vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Clozaril (Clozapine)

Prescription only

Seroquel (quetiapine)

Prescription only
Helps control your thoughts and actions.

Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.

Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

5.0/ 7 average rating with 250 reviewsforSeroquel
Upsides
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Extended release
Price
Lowest price near you
$84.93
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Lowest price near you
$8.4
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Reviews
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250 
56%
think this treatment is worth it
50%
think this treatment works well
27%
think this treatment is a hassle

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Side effects
10possible side effects
  • Drowsiness/Sedation
    39%
  • Salivation
    31%
  • Tachycardia
    25%
  • Dizziness/Vertigo
    19%
  • Constipation
    14%
  • Hypotension
    9%
  • Headache
    7%
  • Tremor
    6%
  • Syncope
    6%
  • Sweating
    6%
See more detailed side effects
10possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
See more detailed side effects
Risks and warnings
  • Low blood pressure | Slow heartbeat | Fainting

    Dehydration

    ...and 1 more risk factors

  • Seizures

    Seizure disorder

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

  • Increased risk of death

    Over 65 and having dementia

  • Increased blood sugar

    Diabetes

  • Return of schizophrenic symptoms

    Stopping Clozaril (Clozapine) suddenly

See more detailed risks and warnings
  • Higher risk of death

    Elderly patients with dementia-related psychosis

  • Suicidal thoughts or behavior

    Children, adolescents, and young adults (<24 years old)

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)

    People with diabetes

    ...and 1 more risk factors

See more detailed risks and warnings