Compare Cogentin vs. Eldepryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cogentin (benztropine)

Eldepryl (selegiline)

Prescription only
Treats Parkinson's disease.

Good for treating tremors caused by Parkinson's and for treating uncontrolled movements in people taking antipsychotics.

Treats Parkinson's disease.

Used with other medicines for Parkinson's disease to boost its effect.

  • Cogentin (benztropine) can be used with other medicines for people with more advanced Parkinson's who continue to have tremors.
  • Works by itself in people under 65 who only have Parkinson's tremors and not other symptoms.
  • Can be used in people who have movement problems because they're taking antipsychotic drugs.
  • Available as generic.
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • Only treats the tremors in Parkinson's and not the other symptoms.
  • Not recommended in people over 65 or those with memory difficulties or problems thinking clearly because they're more likely to have confusion with Cogentin (benztropine).
  • Can't be used in people who have glaucoma.
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
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Side effects
The Cogentin (benztropine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Skin irritation at the patch
  • Headache
  • Insomnia
  • Diarrhea
  • Dry mouth
  • Weight loss of at least 5%
  • Indigestion
  • Rash
  • Sore throat
  • Sinus infection
See more detailed side effects
Risks and warnings
  • Intestinal paralysis

    Taking tricyclic antidepressants

    ...and 1 more risk factors

  • Dehydration

    Over age 65

    ...and 1 more risk factors

  • Heat stroke


    ...and 3 more risk factors

  • Memory problems and confusion

    Over age 65

    ...and 1 more risk factors

See more detailed risks and warnings
  • Increased blood pressure

    Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats

    ...and 1 more risk factors

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Falling asleep during the day

    Taking other medicines for Parkinson's

See more detailed risks and warnings