Compare Cogentin vs. Symmetrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cogentin (benztropine)

Symmetrel (amantadine)

Prescription only
Treats Parkinson's disease.

Good for treating tremors caused by Parkinson's and for treating uncontrolled movements in people taking antipsychotics.

Treats Parkinson's disease, the flu, and side effects from antipsychotic drugs.

Symmetrel (amantadine) is a generic medicine that can be used alone, or with other medicines to treat early Parkinson's disease.

Upsides
  • Cogentin (benztropine) can be used with other medicines for people with more advanced Parkinson's who continue to have tremors.
  • Works by itself in people under 65 who only have Parkinson's tremors and not other symptoms.
  • Can be used in people who have movement problems because they're taking antipsychotic drugs.
  • Available as generic.
  • Symmetrel (amantadine) can be taken by itself or with other medicines to treat the symptoms of early Parkinson's disease, including muscle spasms, tremors, and difficulty with movements.
  • Symmetrel (amantadine) is available in generic and in both a pill and liquid form.
  • Compared to other medicines for Parkinson's disease, the side effects are relatively mild.
Downsides
  • Only treats the tremors in Parkinson's and not the other symptoms.
  • Not recommended in people over 65 or those with memory difficulties or problems thinking clearly because they're more likely to have confusion with Cogentin (benztropine).
  • Can't be used in people who have glaucoma.
  • Symmetrel (amantadine) sometimes has to be taken multiple times a day.
  • Symmetrel (amantadine) can’t stop or cure Parkinson's disease. It can only slow down the progression.
  • You can't take certain forms of the flu vaccine if you're taking Symmetrel (amantadine). Talk to your doctor before receiving vaccines.
  • You can't stop taking Symmetrel (amantadine) suddenly without talking to your doctor since your Parkinson's can get worse.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Liquid
Price
Lowest price near you
$148.94
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Lowest price near you
$38.3
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Reviews
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Side effects
The Cogentin (benztropine) FDA package insert doesn’t have numbers about how common side effects are.
The Symmetrel (amantadine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Intestinal paralysis

    Taking tricyclic antidepressants

    ...and 1 more risk factors

  • Dehydration

    Over age 65

    ...and 1 more risk factors

  • Heat stroke

    Dehydration

    ...and 3 more risk factors

  • Memory problems and confusion

    Over age 65

    ...and 1 more risk factors

See more detailed risks and warnings
  • Deaths from overdosage

    Kidney damage or failure

  • Higher risk of suicide

    Taking Symmetrel (amantadine) for the flu

  • Higher risk of seizures

    History of seizures

  • Heart failure

    Heart failure

    ...and 1 more risk factors

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings