Compare Colcrys vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Colcrys (colchicine)

Prescription only

Zyloprim (allopurinol)

Prescription only
Prevents and treats gout.

Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.

Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

3.7/ 5 average rating with 21 reviewsforAllopurinol
  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Used for
Dosage forms
  • Pill
  • Pill
  • Injection
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21 reviews so far
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Side effects
The Colcrys (colchicine) FDA package insert doesn’t have numbers about how common side effects are.
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Blood disorders
  • Death from overdose
  • Food and medicine interactions
    • Grapefruit
    • Grapefruit juice
    • Protease inhibitors
    • Antifungal antibiotics
    • Calcium channel blockers
    • Cyclosporine
    • Anti-cholesterol medicines
    • Digoxin
  • Muscle pain and breakdown
    • Kidney problems
    • Elderly
    • Use of statins or cholesterol medications
    • Use of cyclosporine
See more detailed risks and warnings
  • More gout attacks
  • Kidney stones
    • History of kidney stones
  • Skin rash
  • Liver disease
  • Sleepiness or dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
See more detailed risks and warnings