Compare Colcrys vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Colcrys
(colchicine)

Zyloprim
(allopurinol)

Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
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Coupons for Colcrys
Best available price for 30 (0.6mg) capsules of colchicine
Coupons for Allopurinol
Best available price for 30 (300mg) tablets of allopurinol
Reviews & ratings
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Reviews for Colcrys (colchicine)
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of people (All ages) say Colcrys (colchicine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Colcrys (colchicine)?
Worth itNot sureNot worth it
Reviews for Zyloprim (allopurinol)
71%
-12% worse vs. Colcrys (colchicine)
52%
-31% worse vs. Colcrys (colchicine)
5%
+12% better vs. Colcrys (colchicine)
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it
Side effects
ColcrysAllopurinol
  • Stomach problems 6%
  • Diarrhea 9%
  • Gout 2%
  • Throat pain 3%
More Colcrys side effects »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
How it works
ColcrysAllopurinol
Colcrys (colchicine) stops the redness and swelling in gout attacks by blocking the cells that cause inflammation from going to the affected joints.Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.
Type of medication
ColcrysAllopurinol
Prescription only
Prescription only
Available as
ColcrysAllopurinol
  • Pill
  • Pill
  • Injection
Used for
ColcrysAllopurinol
Risk factors for serious side effects
ColcrysAllopurinol
  • Grapefruit
  • Grapefruit juice
  • Protease inhibitors
  • Antifungal antibiotics
  • Calcium channel blockers
Detailed Colcrys (colchicine) risks & warnings »
  • History of kidney stones
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Elderly
Detailed Zyloprim (allopurinol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ColcrysAllopurinol
  • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
No interactions related info.
Food
ColcrysAllopurinol
  • Take Colcrys (colchicine) with or without food.
  • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
  • Take with food or milk to prevent an upset stomach.
Kidneys and liver
ColcrysAllopurinol
  • Doses needs to be changed if you have kidney or liver problems.
  • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Sleep
ColcrysAllopurinol
No sleep related info.
  • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
Upsides and benefits
ColcrysAllopurinol
  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
Downsides and risks
ColcrysAllopurinol
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Tips from our pharmacists for people taking the medication
ColcrysAllopurinol
  • Take Colcrys (colchicine) with or without food.
  • At the first sign of a gout attack, take 2 tablets. Don't take more than 3 tablets a day in order to avoid serious side effects.
  • Wait at least 3 days before using Colcrys (colchicine) again, or at least 12 hours if you had been using Colcrys (colchicine) prophylactically.
  • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (colchicine).
  • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
  • Avoid grapefruit and grapefruit juice while taking Colcrys (colchicine).
  • Drink plenty of water while taking Zyloprim (allopurinol).
  • Take with food or milk to prevent an upset stomach.
  • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
  • Your doctor can run blood tests to make sure the medication is working as it should.
  • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
  • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
Learn more
More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Colcrys (colchicine)?
Worth itNot sureNot worth it
More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyloprim (allopurinol)?
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