Compare Colcrys vs. Uloric

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Colcrys (colchicine)

Prescription only

Uloric (febuxostat)

Prescription only
Prevents and treats gout.

Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.

Stops gout attacks.

Uloric (febuxostat) is a medication you take once daily for gout, but it takes a few weeks to kick in.

Upsides
  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
  • Uloric (febuxostat) can be used to lower uric acid if Zyloprim (allopurinol) doesn't work.
  • You only need to take Uloric (febuxostat) once a day.
  • People with mild to moderate kidney disease can use Uloric (febuxostat).
Downsides
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
  • You can have more gout attacks in the first few weeks of taking Uloric (febuxostat).
  • While taking Uloric (febuxostat), you need to drink a lot of fluids to stop kidney stones from forming.
  • You'll have to get your blood checked often with Uloric (febuxostat) therapy.
  • Uloric (febuxostat) doesn't come in generic, so it can be more expensive.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
The Colcrys (colchicine) FDA package insert doesn’t have numbers about how common side effects are.
The Uloric (febuxostat) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Blood disorders
  • Death from overdose
  • Food and medicine interactions
    • Grapefruit
    • Grapefruit juice
    • Protease inhibitors
    • Antifungal antibiotics
    • Calcium channel blockers
    • Cyclosporine
    • Anti-cholesterol medicines
    • Digoxin
  • Muscle pain and breakdown
    • Kidney problems
    • Elderly
    • Use of statins or cholesterol medications
    • Use of cyclosporine
See more detailed risks and warnings
  • Gout flare-ups
  • Blood clots
    • History of stroke or heart attack
  • Liver problems
  • Allergic reaction
    • History of skin reaction to allopurinol
See more detailed risks and warnings