Compare Colcrys vs. Uloric

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Colcrys
(colchicine)

Uloric
(febuxostat)

Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.Prevents gout attacks. Uloric (Febuxostat) is a once a day medication for chronic gout, but it takes a few weeks to kick in.
Reviews & ratings
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Have you used Colcrys (colchicine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Uloric (febuxostat)?
Worth itNot sureNot worth it
Side effects
ColcrysUloric
  • Stomach problems 6%
  • Diarrhea 9%
  • Gout 2%
  • Throat pain 3%
More Colcrys side effects »
  • Liver function abnormalities 6%
  • Rash 1%
More Uloric side effects »
How it works
ColcrysUloric
Colcrys (colchicine) stops the redness and swelling in gout attacks by blocking the cells that cause inflammation from going to the affected joints.Uloric (Febuxostat) is an antigout xanthine oxidase inhibitor. It decreases the build up of uric acid, the enzyme that causes gout.
Type of medication
ColcrysUloric
Prescription onlyPrescription only
Available as
ColcrysUloric
  • Pill
  • Pill
Used for
ColcrysUloric
Risk factors for serious side effects
ColcrysUloric
  • Grapefruit
  • Grapefruit juice
  • Protease inhibitors
  • Antifungal antibiotics
  • Calcium channel blockers
Detailed Colcrys (colchicine) risks & warnings »
    Detailed Uloric (febuxostat) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    ColcrysUloric
    • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
    No interactions related info.
    Alcohol
    ColcrysUloric
    No alcohol related info.
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    Food
    ColcrysUloric
    • Take Colcrys (colchicine) with or without food.
    No food related info.
    Kidneys and liver
    ColcrysUloric
    • Doses needs to be changed if you have kidney or liver problems.
    • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
    Upsides and benefits
    ColcrysUloric
    • Colcrys (colchicine) treats and stops sudden gout attacks.
    • It can be used to prevent gout when people are first starting on allopurinol.
    • Colcrys (colchicine) also treats Familial Mediterranean fever.
    • In one clinical trial, Uloric (Febuxostat) was shown to decrease uric acid to normal levels in over half of the people taking it. It worked better than Zyloprim (allopurinol).
    • You only need to take Uloric (Febuxostat) once a day.
    • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
    Downsides and risks
    ColcrysUloric
    • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
    • Taking Colcrys (colchicine) for too long can cause problems with your blood.
    • Doses needs to be changed if you have kidney or liver problems.
    • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
    • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
    • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
    • Can increase the amount of gout attacks in the first few weeks.
    • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
    • While taking Uloric (Febuxostat), you'll have to get your blood checked often.
    • Doesn't come in a generic version.
    Tips from our pharmacists for people taking the medication
    ColcrysUloric
    • Take Colcrys (colchicine) with or without food.
    • At the first sign of a gout attack, take 2 tablets. Don't take more than 3 tablets a day in order to avoid serious side effects.
    • Wait at least 3 days before using Colcrys (colchicine) again, or at least 12 hours if you had been using Colcrys (colchicine) prophylactically.
    • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (colchicine).
    • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
    • Avoid grapefruit and grapefruit juice while taking Colcrys (colchicine).
    • In the first few months of taking Uloric (Febuxostat), you can still have gout attacks. Don’t give up since it takes a while to fully work. Your doctor can give you another medication to help until it's working well.
    • Take Uloric (Febuxostat) at the same time everyday, with or without food.
    • To make sure Uloric (Febuxostat) is working, have your blood checked often.
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    Learn more
    More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Colcrys (colchicine)?
    Worth itNot sureNot worth it
    More about UloricSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Uloric (febuxostat)?
    Worth itNot sureNot worth it