Compare Combipatch vs. Aygestin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Combipatch (estradiol / norethindrone patch)

Prescription only

Aygestin (norethindrone)

Prescription only
Treats low estrogen and relieves menopause symptoms.

Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.

Regulates your menstrual cycle and treats irregular bleeding.

Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.

3.6/ 7 average rating with 30 reviewsforAygestin
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Pain caused by endometriosis
  • Balances hormones in women who don't have regular monthly periods
  • Balances hormones in women who have unusual monthly periods
Dosage forms
  • Patch
  • Pill
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Side effects
10possible side effects
  • Breast pain
  • Menstrual cramps
  • Headache
  • Skin irritation
  • Pain
  • Stuffy nose
  • Menstrual problems
  • Back pain
  • Flu like symptoms
  • Diarrhea
See more detailed side effects
The Aygestin (norethindrone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Dementia

    Aged 65 or older

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings
  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Depression

    History of depression

  • Changes in blood sugar levels


  • Liver problems

    History of liver problems

  • High cholesterol levels

    High cholesterol levels

See more detailed risks and warnings