Compare Combipatch vs. Aygestin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Combipatch
(estradiol / norethindrone patch)

Aygestin
(norethindrone)

Treats low estrogen and relieves menopause symptoms. Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.
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Coupons for Combipatch
Best available price for 8 (8 patches of 0.05mg/0.14mg) packages of combipatch
Coupons for Aygestin
Best available price for 30 (5mg) tablets of aygestin
Reviews & ratings
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Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it
Reviews for Aygestin
40%
+52% better vs. Combipatch
23%
+69% better vs. Combipatch
23%
+23% better vs. Combipatch
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it
Side effects
CombipatchAygestin
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu syndrome 2%
  • Papanicolaou smear suspicious 3%
  • Muscle weakness 4%
  • Abdominal pain 3%
More Combipatch side effects »

The Aygestin FDA package insert doesn’t have numbers about how common side effects are.

More about Aygestin side effects »
How it works
CombipatchAygestin
Combipatch (Estradiol / Norethindrone Patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Aygestin (norethindrone) contains norethindrone, a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).
Type of medication
CombipatchAygestin
Prescription onlyPrescription only
Available as
CombipatchAygestin
  • Patch
  • Pill
Used for
CombipatchAygestin
  • Hot Flashes And Night Sweats
  • Pain Caused By Endometriosis
Risk factors for serious side effects
CombipatchAygestin
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • History of depression
Detailed Aygestin (norethindrone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Kidneys and liver
CombipatchAygestin
No kidneys and liver related info.
  • Aygestin (norethindrone) is broken down by the liver, so if the liver is damaged, the drug can build up in your body. Tell your doctor if you've had liver disease or damage. Your doctor will have to change Aygestin (norethindrone) to a different medicine.
Pain
CombipatchAygestin
No pain related info.
  • Aygestin (norethindrone) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
Weight
CombipatchAygestin
  • Combipatch (Estradiol / Norethindrone Patch) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Can make you gain weight.
Upsides and benefits
CombipatchAygestin
  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
Downsides and risks
CombipatchAygestin
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
Tips from our pharmacists for people taking the medication
CombipatchAygestin
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • The dose of Aygestin (norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it at the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (norethindrone).
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
Learn more
More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it
More about AygestinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it