Compare Combipatch vs. Divigel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Combipatch
(Estradiol / Norethindrone Patch)

Divigel
(Estradiol Gel)

Treats low estrogen and relieves menopause symptoms. Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.
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Reviews & ratings
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Have you used Combipatch (Estradiol / Norethindrone Patch)?
Worth itNot sureNot worth it

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Have you used Divigel (Estradiol Gel)?
Worth itNot sureNot worth it
Side effects
CombipatchDivigel
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu syndrome 2%
  • Papanicolaou smear suspicious 3%
  • Muscle weakness 4%
  • Abdominal pain 3%
More Combipatch side effects »
  • Common cold 2%
  • Ear, nose, or throat infection 4%
  • Metrorrhagia 2%
  • Breast tenderness 1%
More Divigel side effects »
How it works
CombipatchDivigel
Combipatch (Estradiol / Norethindrone Patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
CombipatchDivigel
Prescription only
Prescription only
Available as
CombipatchDivigel
  • Patch
  • Cream, gel, or ointment
Used for
CombipatchDivigel
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
CombipatchDivigel
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Combipatch (Estradiol / Norethindrone Patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
    Detailed Divigel (Estradiol Gel) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    CombipatchDivigel
    No alcohol related info.
    • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Weight
    CombipatchDivigel
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Combipatch (Estradiol / Norethindrone Patch) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    Upsides and benefits
    CombipatchDivigel
    • Twice-a-week patch. Good for people who don't want to take daily pills.
    • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
    • Fewer side effects than pills since patches contain lower amounts of hormones.
    • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
    • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
    • Good for people who don't want to take daily pills.
    • The pre-measured packets are easy to use and can be taken anywhere.
    • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
    • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
    • Divigel (Estradiol Gel) is available in 3 strengths.
    • Very few women (less than 1%) had skin irritation from the medicine.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Downsides and risks
    CombipatchDivigel
    • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
    • Increases your risk of developing blood clots and stroke.
    • You may get irregular bleeding and spotting that can last a few months to a year.
    • Patch can fall off.
    • Can be expensive since it's only available as a brand name product.
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    CombipatchDivigel
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
    • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
    • Wash your hands well after applying the gel.
    • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Learn more
    More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Combipatch (Estradiol / Norethindrone Patch)?
    Worth itNot sureNot worth it
    More about DivigelSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Divigel (Estradiol Gel)?
    Worth itNot sureNot worth it