Compare Combivent vs. Spiriva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Combivent
(ipratropium / albuterol)

Spiriva
(tiotropium)

Makes it easier to breathe. Combivent (Ipratropium / Albuterol) is good for people who need 2 medicines to relieve their COPD symptoms, but you need to be okay with taking it four times a day.Makes it easier to breathe. Spiriva (Tiotropium) works well to reduce COPD symptoms and flare-ups with fewer side effects than some medicines that open airways, but you have to use it every day.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.62Combivent
Reviews for Combivent
63%
of people (All ages) say Combivent is worth it
37%
say it works well
13%
say it's a big hassle
142 reviews
Have you used Combivent (ipratropium / albuterol)?
Worth itNot sureNot worth it
Reviews for Spiriva
64%
-1% worse vs. Combivent
46%
-9% worse vs. Combivent
8%
-5% worse vs. Combivent
Have you used Spiriva (tiotropium)?
Worth itNot sureNot worth it
Side effects
CombiventSpiriva
  • Bronchitis 12%
  • Ear, nose, or throat infection 11%
  • Headache 6%
  • Shortness of breath 5%
  • Coughing 4%
  • Pain 3%
  • Respiratory disorders 3%
  • Nausea 2%
  • Sore throat 2%
  • Sinus inflammation 2%
More Combivent side effects »
  • Respiratory tract infection 4%
  • Dry mouth 13%
  • Sore throat 2%
  • Sinus inflammation 2%
  • Urinary tract infection 2%
  • Chest pain (non-specific) 2%
  • Headache 1%
  • Indigestion 1%
More Spiriva side effects »
How it works
CombiventSpiriva
Combivent (Ipratropium / Albuterol) is a combination medicine. It contains two bronchodilators (ipratropium and albuterol), which relax muscles in your lungs to open airways and make breathing easier.Spiriva (Tiotropium) is a bronchodilator. It relaxes muscles in your lungs to open your airways and make breathing easier.
Type of medication
CombiventSpiriva
Prescription onlyPrescription only
Available as
CombiventSpiriva
  • Inhaler
  • Inhaler
Used for
CombiventSpiriva
Risk factors for serious side effects
CombiventSpiriva
  • History of rapid heartbeat
  • History of high blood pressure
  • history of heart failure or chest pain.
  • History of narrow-angle glaucoma
  • History of high eye pressure
Detailed Combivent (ipratropium / albuterol) risks & warnings »
  • History of atropine allergic reaction
  • History of narrow-angle glaucoma
  • History of urinary bladder blockage (urinary obstruction)
  • History of enlarged prostate
  • Severe milk protein allergy
Detailed Spiriva (tiotropium) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
CombiventSpiriva
No kidneys and liver related info.
  • The kidney is mainly responsible for removing Spiriva (Tiotropium) from the body so people with kidney disease or reduced function need to be watched closely. Spiriva (Tiotropium) can build up in the body and cause certain side effects. Tell your doctor if you develop dry mouth, blurry vision, confusion, sweating, increased heart rate or constipation. You may need to discuss other medication options to treat your COPD.
Upsides and benefits
CombiventSpiriva
  • 2-in-1 medicine that opens airways and makes it easier to breathe. Medicines are more effective together than alone.
  • Effectively relieves COPD and asthma symptoms.
  • Respimat formulation has a clear display for dosing, doesn't require shaking, and only needs one inhalation per dose.
  • Helps you breathe easier and lessens the need for a fast-acting (rescue) inhaler.
  • Reduces flare-ups and hospitalizations with fewer side effects compared to some other medicines that open airways.
  • You only need to take it once a day.
Downsides and risks
CombiventSpiriva
  • You have to use Combivent four times a day.
  • Can make your heart race.
  • Can make symptoms of enlarged prostate or urinary blockage worse.
  • Can worsen a certain type of glaucoma.
  • Won't cure your COPD (but it will relieve your symptoms).
  • You'll need to use this medicine for a long time, and you have to take it every day.
  • Can make symptoms of enlarged prostate or urinary blockage worse.
  • Can worsen a certain type of glaucoma.
  • You might feel dizzy or have blurry vision while taking this medicine.
Tips from our pharmacists for people taking the medication
CombiventSpiriva
  • Starts working in 15 to 30 minutes, and lasts about 4 to 6 hours.
  • Make sure to read the instructions about how to set up your first dose.
  • Clean the mouthpiece with a damp cloth once a week.
  • The inhaler shows you how much medication you have left so you can plan ahead for refills.
  • Don't take it more often or change your dose without talking to your doctor first.
  • Tell your doctor if the medication stops working or if your symptoms get worse.
  • One type of inhaler contains soya lecithin, so don't use if you have soybean, peanut, or allergies to atropine.
  • Don't swallow the capsule. Insert the capsule into an inhaler device only.
  • Use daily to control your COPD.
  • Starts working the first few hours, but it may take longer to feel full effects.
  • Prevents breathing problems, but doesn't stop sudden cough or wheezing once they start.
  • Don't breathe out into the inhaler.
  • You might feel dizzy and notice changes in your vision.
  • Don't use it if you have an allergy to atropine.
  • Contains lactose, so don't use it if you're allergic to milk protein.
Learn more
More about CombiventSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combivent (ipratropium / albuterol)?
Worth itNot sureNot worth it
More about SpirivaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Spiriva (tiotropium)?
Worth itNot sureNot worth it