Compare Complera vs. Atripla

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats HIV infection

Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.

Treats HIV infection.

Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.

Upsides
  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
Downsides
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$2741.37
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Lowest price
$2606.20
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Reviews
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Side effects
3possible side effects
  • Headache
    2%
  • Depressive disorders
    2%
  • Insomnia
    2%
See more detailed side effects
13possible side effects
  • Diarrhea
    9%
  • Nausea
    9%
  • Fatigue
    9%
  • Depression
    9%
  • Sinusitis
    8%
  • Upper respiratory tract infections
    8%
  • Dizziness
    8%
  • Rash Event
    7%
  • Headache
    6%
  • Nasopharyngitis
    5%
  • Anxiety
    5%
  • Insomnia
    5%
  • Vomiting
    2%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Cannot be used to treat Hepatitis B Virus (HBV)
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental health problems
  • Decreased bone mineral density
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Concurrent use of drugs known to harm kidneys
  • Hypersensitivity (allergic) reactions
    • Prior severe allergic reaction to Complera (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.
See more detailed risks and warnings
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Cannot be used to treat Hepatitis B Virus (HBV)
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental health problems
    • History of drug abuse
  • Liver damage
    • History of liver disease
    • Taking alcohol or other drugs that can damage the liver.
  • Bone loss/osteoporosis
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Taking other medicines that can harm the kidneys
See more detailed risks and warnings