Compare Complera vs. Atripla

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Complera
(emtricitabine / rilpivirine / tenofovir)

Atripla
(efavirenz / emtricitabine / tenofovir)

Treats HIV infection Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.Treats HIV infection. Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.
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Best available price for 30 (600mg/200mg/300mg) tablets of efavirenz / emtricitabine / tenofovir
Reviews & ratings
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Reviews for Complera (emtricitabine / rilpivirine / tenofovir)
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of people (All ages) say Complera (emtricitabine / rilpivirine / tenofovir) is worth it
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say it works well
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say it's a big hassle
Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Atripla (efavirenz / emtricitabine / tenofovir)
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Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
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Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
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+100% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
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Side effects
CompleraAtripla
  • Headache 2%
  • Depressive disorders 2%
  • Sleep difficulty 2%
More Complera side effects »
  • Diarrhea 9%
  • Low mood disorder 9%
  • Fatigue 9%
  • Nausea 9%
  • Sinus inflammation 8%
  • Ear, nose, or throat infection 8%
  • Dizziness 8%
  • Rash event 7%
  • Headache 6%
  • Anxiety 5%
More Atripla side effects »
How it works
CompleraAtripla
Complera (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.
Type of medication
CompleraAtripla
Prescription only
Prescription only
Available as
CompleraAtripla
  • Pill
  • Pill
Used for
CompleraAtripla
Risk factors for serious side effects
CompleraAtripla
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Complera (emtricitabine / rilpivirine / tenofovir) risks & warnings »
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Atripla (efavirenz / emtricitabine / tenofovir) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
CompleraAtripla
  • Not recommended for patients with kidney damage.
  • Complera (emtricitabine / rilpivirine / tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Complera (emtricitabine / rilpivirine / tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
  • People on Complera (emtricitabine / rilpivirine / tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles. Your doctor will do blood tests to check your kidneys regularly while you're taking Complera (emtricitabine / rilpivirine / tenofovir).
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
  • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
Upsides and benefits
CompleraAtripla
  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
Downsides and risks
CompleraAtripla
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
Tips from our pharmacists for people taking the medication
CompleraAtripla
  • Complera (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
  • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
  • Take Complera (emtricitabine / rilpivirine / tenofovir) with at least a light meal with 12 grams of fat. Some examples that the makers of Complera (emtricitabine / rilpivirine / tenofovir) list are toast with peanut butter & fruit, roast beef sandwich, or a grilled chicken caesar salad.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
  • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Atripla (efavirenz / emtricitabine / tenofovir). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
  • Should be taken on an empty stomach at bedtime to reduce side effects.
  • Women taking Atripla (efavirenz / emtricitabine / tenofovir) should be on effective form(s) of contraception, as Atripla (efavirenz / emtricitabine / tenofovir) can cause birth defects.
  • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
Learn more
More about CompleraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it
More about AtriplaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
Worth itNot sureNot worth it