Compare Complera vs. Epzicom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats HIV infection

Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.

Works with other medicines to treat HIV infection.

Epzicom (abacavir / lamivudine) contains two medicines in one tablet, used with other medicines, to treat HIV infection. Your doctor does need to test you before you start it to make sure you don't get an allergic reaction.

  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • Epzicom (abacavir / lamivudine) contains two first choice medicines used in combination with other medicines to treat HIV infections.
  • Compared to other HIV medicines, Epzicom (abacavir / lamivudine) does not have as many drug interactions with other medicines.
  • Can be taken with or without food.
  • Epzicom (abacavir / lamivudine) can be taken by children weighng at least 55lbs (25kg) or more.
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Epzicom (abacavir / lamivudine) isn't recommended if you'll need to adjust the dose of medications due to problems like kidney and/or liver damage.
  • Epzicom (abacavir / lamivudine) can increase your risk of heart attack, especially if you have other heart-related issues such as high blood pressure, high cholesterol, diabetes, or if you smoke.
  • Severe allergic reactions have happened in some patients taking Epzicom (abacavir / lamivudine). Your doctor will test you for any possible risk of reaction before starting Epzicom (abacavir / lamivudine).
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
3possible side effects
  • Headache
  • Depressive disorders
  • Insomnia
See more detailed side effects
13possible side effects
  • Severe allergic reaction
  • Insomnia
  • Depression/Depressed mood
  • Headache/Migraine
  • Fatigue/Malaise
  • Dizziness/Vertigo
  • Nausea
  • Diarrhea
  • Rash
  • Fever
  • Abdominal pain & inflammation
  • Abnormal dreams
  • Anxiety
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Cannot be used to treat Hepatitis B Virus (HBV)
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental health problems
  • Decreased bone mineral density
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Concurrent use of drugs known to harm kidneys
  • Hypersensitivity (allergic) reactions
    • Prior severe allergic reaction to Complera (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.
See more detailed risks and warnings
  • Severe allergic reaction
    • Previous allergic reaction to Triumeq or abacavir
    • Presence of HLA-B*5701 gene
  • Lactic acidosis and Fatty liver
    • Liver disease
    • Women
    • Obesity
  • Acute exacerbation of hepatitis B virus (HBV)
    • Hepatitis B virus
  • Fat redistribution
    • HIV treatment
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Heart attack
    • History of coronary heart disease
    • High blood pressure
    • Dyslipidemia
    • Diabetes mellitus
    • Smoking
See more detailed risks and warnings