Compare Complera vs. Isentress

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Complera (emtricitabine / rilpivirine / tenofovir)

Prescription only

Isentress (raltegravir)

Prescription only
Treats HIV infection

Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.

Works with other medicications to treat HIV infection.

Isentress (raltegravir) is considered a first choice to be used with other medications for treating HIV, but it can have more side effects than other similar medicines.

Upsides
  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • Isentress (raltegravir) is a first choice treatment to use together with other medications to treat HIV.
  • If you have difficulty swallowing the tablet, there is a chewable tablet or oral suspension available.
  • Can be used by children 4 weeks and older.
  • People with mild to moderate kidney or liver damage can use Isentress (raltegravir).
Downsides
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • It might be hard to remember to take Isentress (raltegravir) two times a day. Other similar medicines are once a day.
  • The chewable tablets contain phenylalanine and should be avoided in people who have phenylketonuria.
  • Isentress (raltegravir) cannot be used alone to treat or prevent HIV. It must be used together with other medications.
  • Not available as part of a combination tablet, so you'll have to take more tablets daily compared to other combinations.
Used for
Dosage forms
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Price
Lowest price near you
$2741.37
Find instant savings
Lowest price near you
$1424.38
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
3possible side effects
  • Headache
    2%
  • Depressive disorders
    2%
  • Insomnia
    2%
See more detailed side effects
5possible side effects
  • Headache
    4%
  • Insomnia
    4%
  • Nausea
    3%
  • Fatigue
    2%
  • Dizziness
    2%
See more detailed side effects
Risks and warnings
  • Lactic acidosis | Enlarged, fatty liver

    Liver disease

    ...and 2 more risk factors

  • Cannot be used to treat Hepatitis B Virus (HBV)

    Hepatitis B Virus infection

  • Mood and behavior changes

    History of mental health problems

  • Decreased bone mineral density

    History of bone fractures

    ...and 1 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 1 more risk factors

  • Hypersensitivity (allergic) reactions

    Prior severe allergic reaction to Complera (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.

See more detailed risks and warnings
  • Severe skin reactions

    Prior severe allergic reaction to Isentress

  • Allergic reactions

    Prior severe allergic reaction to Isentress

  • Rhabdomyolysis (Muscle damage)

    Concurrent use of other drugs which can cause muscle pain/damage

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

See more detailed risks and warnings