Compare Complera vs. Isentress

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Complera
(emtricitabine / rilpivirine / tenofovir)

Isentress
(raltegravir)

Treats HIV infection Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.Works with other medicines to treat HIV infection. This is the first medication approved as an Integrase Inhibitor (InSTI), so it may be a great, but somewhat expensive, option for people who have already tried other drugs and need another option.
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Coupons for Complera
Best available price for 30 (200mg/25mg/300mg) tablets of complera
Coupons for Isentress
Best available price for 60 (400mg) tablets of isentress
Reviews & ratings
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Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it

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Have you used Isentress (raltegravir)?
Worth itNot sureNot worth it
Side effects
CompleraIsentress
  • Headache 2%
  • Depressive disorders 2%
  • Sleep difficulty 2%
More Complera side effects »

We haven’t found good data for Isentress side effects.

FDA side effect reports for Isentress »
How it works
CompleraIsentress
Complera (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Isentress stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
CompleraIsentress
Prescription onlyPrescription only
Available as
CompleraIsentress
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Used for
CompleraIsentress
  • HIV Infection
Risk factors for serious side effects
CompleraIsentress
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Complera (emtricitabine / rilpivirine / tenofovir) risks & warnings »
  • Prior severe allergic reaction to Isentress
  • Phenylketonuria
  • Certain drugs can increase the dose of Isentress in the body
  • HIV
Detailed Isentress (raltegravir) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CompleraIsentress
No food related info.
  • Take Isentress with or without food.
Kidneys and liver
CompleraIsentress
  • Complera (emtricitabine / rilpivirine / tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Complera (emtricitabine / rilpivirine / tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
  • People on Complera (emtricitabine / rilpivirine / tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles. Your doctor will do blood tests to check your kidneys regularly while you're taking Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients with kidney damage.
No kidneys and liver related info.
Pain
CompleraIsentress
No pain related info.
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis), and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
Upsides and benefits
CompleraIsentress
  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • If having difficulty swallowing the tablet, consider the chewable tablet or oral suspension.
  • Only one tablet taken two times a day.
  • Can be used for kids 4 weeks and older.
  • May be helpful if other HIV drugs have stopped working since Isentress works differently than most HIV drugs.
Downsides and risks
CompleraIsentress
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Tablets, chewable tablets, and the oral suspension all have different doses, so talk to your doctor if you want to switch from one to another.
  • The oral suspension has to be taken within 30 minutes of mixing it.
  • Avoid taking antacids that contain aluminum and/or magnesium while taking Isentress.
  • Let your doctor know right away if while taking Isentress you begin to feel unexplained muscle pain.
Tips from our pharmacists for people taking the medication
CompleraIsentress
  • Complera (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
  • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
  • Take Complera (emtricitabine / rilpivirine / tenofovir) with at least a light meal with 12 grams of fat. Some examples that the makers of Complera (emtricitabine / rilpivirine / tenofovir) list are toast with peanut butter & fruit, roast beef sandwich, or a grilled chicken caesar salad.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
  • Set two times during the day, one in the morning and one in the evening that you will remember to take Isentress.
  • Take Isentress with or without food.
  • Isentress can make you tired, so avoid other medications or drinks that will add to the problem.
  • If being used for kids, the dose of Isentress will continue to change as they grow, so keep in touch with their doctor.
Learn more
More about CompleraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it
More about IsentressSide effectsReviews & ratingsFDA package insert
Have you used Isentress (raltegravir)?
Worth itNot sureNot worth it