Compare Complera vs. Prezista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Complera
(emtricitabine / rilpivirine / tenofovir)

Prezista
(darunavir)

Treats HIV infection Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.Coming soon.
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Coupons for Complera
Best available price for 30 (200mg/25mg/300mg) tablets of complera
Coupons for Prezista
Best available price for 30 (800mg) tablets of prezista
Reviews & ratings
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Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it

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Have you used Prezista (darunavir)?
Worth itNot sureNot worth it
Side effects
CompleraPrezista
  • Headache 2%
  • Depressive disorders 2%
  • Sleep difficulty 2%
More Complera side effects »

We haven’t found good data for Prezista side effects.

FDA side effect reports for Prezista »
How it works
CompleraPrezista
Complera (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Coming soon.
Type of medication
CompleraPrezista
Prescription only
Available as
CompleraPrezista
  • Pill
  • Pill
  • Liquid
Used for
CompleraPrezista
  • HIV Infection
Risk factors for serious side effects
CompleraPrezista
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Complera (emtricitabine / rilpivirine / tenofovir) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    CompleraPrezista
    • Complera (emtricitabine / rilpivirine / tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Complera (emtricitabine / rilpivirine / tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
    • People on Complera (emtricitabine / rilpivirine / tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles. Your doctor will do blood tests to check your kidneys regularly while you're taking Complera (emtricitabine / rilpivirine / tenofovir).
    • Not recommended for patients with kidney damage.
    No kidneys and liver related info.
    Upsides and benefits
    CompleraPrezista
    • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
    Coming soon
    Downsides and risks
    CompleraPrezista
    • Must be taken with a light meal which includes fat.
    • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
    • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
    • Not recommended for patients with kidney damage.
    • Can weaken your bones.
    Coming soon
    Tips from our pharmacists for people taking the medication
    CompleraPrezista
    • Complera (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
    • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
    • Take Complera (emtricitabine / rilpivirine / tenofovir) with at least a light meal with 12 grams of fat. Some examples that the makers of Complera (emtricitabine / rilpivirine / tenofovir) list are toast with peanut butter & fruit, roast beef sandwich, or a grilled chicken caesar salad.
    • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
    Coming soon
    Learn more
    More about CompleraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
    Worth itNot sureNot worth it
    More about PrezistaSide effectsFDA package insert
    Have you used Prezista (darunavir)?
    Worth itNot sureNot worth it