Compare Complera vs. Viread

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Complera (emtricitabine / rilpivirine / tenofovir)

Prescription only
Treats HIV infection

Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.

Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus.

Viread (tenofovir) is a first-line choice to be used in combination with other medications to treat HIV. Viread (tenofovir) is also a first-line choice in treating HBV.

Upsides
  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
  • Can be used with other medications to prevent HIV infection after an exposure.
  • Taken only once daily, with or without food.
  • There are newer formulations of Viread (tenofovir) available that are safer on your kidneys.
  • If tablets are hard for you to swallow, Viread (tenofovir) is available in a powder that's mixed with soft foods.
Downsides
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Viread (tenofovir) can't be used on its own to treat HIV infection.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Might worsen hepatitis B infections if you suddenly stop taking it.
Used for
Dosage forms
  • Pill
  • Pill
  • Powder
Price
Lowest price near you
$2741.37
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Lowest price near you
$1094.94
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Reviews
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Side effects
3possible side effects
  • Headache
    2%
  • Depressive disorders
    2%
  • Insomnia
    2%
See more detailed side effects
1possible side effects
  • Nausea
    9%
See more detailed side effects
Risks and warnings
  • Lactic acidosis | Enlarged, fatty liver

    Liver disease

    ...and 2 more risk factors

  • Cannot be used to treat Hepatitis B Virus (HBV)

    Hepatitis B Virus infection

  • Mood and behavior changes

    History of mental health problems

  • Decreased bone mineral density

    History of bone fractures

    ...and 1 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 1 more risk factors

  • Hypersensitivity (allergic) reactions

    Prior severe allergic reaction to Complera (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.

See more detailed risks and warnings
  • Lactic acidosis | Enlarged, fatty liver

    Liver disease

    ...and 2 more risk factors

  • Cannot be used to treat Hepatitis B Virus (HBV)

    Hepatitis B Virus infection

  • Mood and behavior changes

    History of mental illness

  • Decreased bone mineral density

    History of bone fractures

    ...and 1 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 1 more risk factors

  • Hypersensitivity (allergic) reactions

    Prior severe allergic reaction to Viread (tenofovir) or any of its individual drug components.

See more detailed risks and warnings