Compare Compro vs. Scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Compro
(Prochlorperazine)

Transderm-Scop
(Scopolamine)

Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.95Compro
Reviews for Compro (Prochlorperazine)
45%
of people say Compro (Prochlorperazine) is worth it
35%
say it works well
35%
say it's a big hassle
Reviews for Transderm-Scop (Scopolamine)
72%
+27% vs. Compro (Prochlorperazine)
56%
+21% vs. Compro (Prochlorperazine)
20%
+15% vs. Compro (Prochlorperazine)
Side effects
ComproScopolamine

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
  • Any side effect 9%
  • Drowsiness 4%
  • Visual impairment 2%
  • Agitation 2%
  • Confusion 1%
  • Sore throat 1%
More Scopolamine side effects »
How it works
ComproScopolamine
Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
ComproScopolamine
Anti-nausea, Antipsychotic
Antidopaminergic
Prescription only
Anti-nausea
Anticholinergic
Prescription only
Available as
ComproScopolamine
  • Pill
  • Suppository
  • Patch
Used for (click to learn more)
ComproScopolamine
Risk factors for serious side effects
ComproScopolamine
  • Over age 65
  • Dementia
  • Taking antipsychotics
  • History of seizures
  • Age over 65
      • Taking with alcohol
      • Taking other medicines that make you less alert
      Detailed Compro (Prochlorperazine) risks & warnings »
      • Glaucoma
        • Doing an MRI
        • History of seizures
        • History of psychosis
        • Taking with alcohol
        • Taking other medicines that make you less alert
        Detailed Transderm-Scop (Scopolamine) risks & warnings »
        Pregnancy category
        ComproScopolamine
        NFDA pregnancy category (Unknown)

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Don't drink alcohol to avoid intense side effects.
        • You have to avoid alcohol while on the medication.
        • Don't drink alcohol if you have to use the patch.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        ComproScopolamine
        • Available in generic, so it's cheap.
        • Can be taken by mouth, as a shot, or rectally.
        • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
        • Even though there's no generic version available, it's inexpensive.
        • Placed on the skin so it can be used if you can't keep anything in your stomach.
        • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
        Downsides and risks
        ComproScopolamine
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Can't be used by people over 65 because they can be more affected by the side effects.
        • It can make you more likely to get heatstroke.
        • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
        • Takes about 4 hours for it to start working.
        • You have to avoid alcohol while on the medication.
        Tips from our pharmacists for people taking the medication
        ComproScopolamine
        • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
        • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
        • Don't drink alcohol to avoid intense side effects.
        • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
        • Avoid using if you experience seizures (epilepsy).
        • Don't use if you're 65 or older because you're at higher risk for serious side effects.
        • Wash your hands after you place the patch.
        • Don't touch or rub your eyes after putting on the patch before washing your hands.
        • Can cause blurry vision and sleepiness.
        • Take the patch off if you have to do an MRI.
        • Don't drink alcohol if you have to use the patch.
        • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
        Learn more
        More about ComproSide effectsReviews & ratingsAlternativesFDA package insert
        More about ScopolamineSide effectsReviews & ratingsAlternativesFDA package insert