Compare Compro vs. Scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Compro
(Prochlorperazine)

Transderm-Scop
(Scopolamine)

Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.
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Reviews & ratings
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Have you used Compro (Prochlorperazine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Transderm-Scop (Scopolamine)?
Worth itNot sureNot worth it
Side effects
ComproScopolamine

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
  • Any side effect 9%
  • Drowsiness 4%
  • Visual impairment 2%
  • Agitation 2%
  • Confusion 1%
  • Sore throat 1%
More Scopolamine side effects »
How it works
ComproScopolamine
Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
ComproScopolamine
Anti-nausea, Antipsychotic
Antidopaminergic
Prescription only
Anti-nausea
Anticholinergic
Prescription only
Available as
ComproScopolamine
  • Pill
  • Suppository
  • Patch
Used for (click to learn more)
ComproScopolamine
Risk factors for serious side effects
ComproScopolamine
  • Over age 65
  • Dementia
  • Taking antipsychotics
  • History of seizures
  • Age over 65
      • Taking with alcohol
      • Taking other medicines that make you less alert
      Detailed Compro (Prochlorperazine) risks & warnings »
      • Glaucoma
        • Doing an MRI
        • History of seizures
        • History of psychosis
        • Taking with alcohol
        • Taking other medicines that make you less alert
        Detailed Transderm-Scop (Scopolamine) risks & warnings »
        Pregnancy

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        ComproScopolamine
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Don't drink alcohol to avoid intense side effects.
        • You have to avoid alcohol while on the medication.
        • Don't drink alcohol if you have to use the patch.
        Pain
        ComproScopolamine
        • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
        No pain related info.
        Sleep
        ComproScopolamine
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
        No sleep related info.
        Upsides and benefits
        ComproScopolamine
        • Available in generic, so it's cheap.
        • Can be taken by mouth, as a shot, or rectally.
        • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
        • Even though there's no generic version available, it's inexpensive.
        • Placed on the skin so it can be used if you can't keep anything in your stomach.
        • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
        Downsides and risks
        ComproScopolamine
        • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
        • Can't be used by people over 65 because they can be more affected by the side effects.
        • It can make you more likely to get heatstroke.
        • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
        • Takes about 4 hours for it to start working.
        • You have to avoid alcohol while on the medication.
        Tips from our pharmacists for people taking the medication
        ComproScopolamine
        • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
        • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
        • Don't drink alcohol to avoid intense side effects.
        • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
        • Avoid using if you experience seizures (epilepsy).
        • Don't use if you're 65 or older because you're at higher risk for serious side effects.
        • Wash your hands after you place the patch.
        • Don't touch or rub your eyes after putting on the patch before washing your hands.
        • Can cause blurry vision and sleepiness.
        • Take the patch off if you have to do an MRI.
        • Don't drink alcohol if you have to use the patch.
        • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
        Learn more
        More about ComproSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Compro (Prochlorperazine)?
        Worth itNot sureNot worth it
        More about ScopolamineSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Transderm-Scop (Scopolamine)?
        Worth itNot sureNot worth it