Compare Copaxone vs. Aubagio

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Copaxone (Glatiramer)

Prescription only

Aubagio (Teriflunomide)

Prescription only
Lowers the frequency of multiple sclerosis exacerbations.

Copaxone (Glatiramer) is an injectable medicine that's effective for relapsing, remitting MS. It has fewer side effects than other meds, but the self-injections are needed frequently.

4.2/ 7 average rating with 30 reviewsforCopaxone
Treats relapsing forms of MS.

Aubagio (Teriflunomide) is an oral medicine that effectively reduces the number of flare-ups, slows physical changes, and decreases the number of new brain lesions in relapsing MS. Because it stays in the body for so long, if you have a serious reaction or possible pregnancy you'll need to have it quickly removed with another medicine.

3.3/ 7 average rating with 23 reviewsforAubagio
  • One of the main treatments for relapsing multiple sclerosis (MS) that has been around for many years.
  • Helps reduce the frequency of MS relapse episodes.
  • Fewer side effects than other injectable MS medicines, like interferons.
  • Can be helpful in maintaining nerve functions.
  • Likely safe to use during pregnancy.
  • Copaxone (Glatiramer) is a possible treatment for primary-progressive MS (PPMS) even though the clinical evidence is not conclusive (there are currently no approved treatments for PPMS).
  • You can take it by mouth.
  • It comes a 7 mg and 14mg dose and only needs to be taken once a day, with or without food.
  • In clinical studies, Aubagio reduced relapses, slowed disability, and decreased the number of new brain lesions compared to sugar pill (placebo).
  • Although it may not work for everyone, most people felt it wasn't much of a hassle.
  • Requires injections, either day or every other day (but no more than three times a week), depending on the dose you're taking.
  • Injection site reactions are common with pain, redness, swelling, and lipoatrophy (loss of fat under the skin where the injection is made).
  • Doesn't stop the progression of MS.
  • Some people have nausea and diarrhea when they start treatment. In most cases, these effects are mild and get better over time.
  • Aubagio can cause your hair to thin. This is temporary, and your hair will go back to normal after a few months.
  • You should have certain lab tests to make sure you don't have any problems from taking Aubagio. These include: complete blood count and liver enzyme testing within 6 months before you start treatment, tuberculosis (TB) screening, and blood pressure.
  • Numbness or tingling in your hands and feet (peripheral neuropathy), different from MS was reported more often than with sugar pill (placebo)
  • Aubagio may stay in your blood up to 2 years after you stop taking it. You can quickly remove Aubagio the accelerated elimination procedure, but symptoms of your disease may return.
  • You can't take it if you're pregnant.
Used for
Dosage forms
  • Injection
  • Pill
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Side effects
The Copaxone (Glatiramer) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Moderate hypophospatemia
See more detailed side effects
Risks and warnings
See more detailed risks and warnings
  • Liver problems

    Taking medicines that affect your liver or cause liver injury

  • Serious skin reactions

    Reaction to leflunomide

  • Numbness in extremities (hands and feet)

    Age 60 or older

    ...and 2 more risk factors

  • Serious Infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Kidney problems

    High uric acid levels

  • High potassium

    Acute kidney failure

  • Respiratory problems

    History of lung disease

  • High blood pressure

    History of high blood pressure

See more detailed risks and warnings