Compare Coreg vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coreg
(Carvedilol)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Coreg (Carvedilol) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
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4.79Coreg
Reviews for Coreg (Carvedilol)
53%
of people (All ages) say Coreg (Carvedilol) is worth it
46%
say it works well
18%
say it's a big hassle
406 reviews
Have you used Coreg (Carvedilol)?
Worth itNot sureNot worth it
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
6% vs. Coreg (Carvedilol)
31%
15% vs. Coreg (Carvedilol)
16%
+2% vs. Coreg (Carvedilol)
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Side effects
CoregHydrochlorothiazide
  • Leg or ankle swelling 1%
More Coreg side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
CoregHydrochlorothiazide
Coreg (Carvedilol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
CoregHydrochlorothiazide
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
CoregHydrochlorothiazide
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
CoregHydrochlorothiazide
Risk factors for serious side effects
CoregHydrochlorothiazide
  • Abrupt discontinuation of Coreg (Carvedilol)
  • Congestive heart failure
  • Increasing the dose of Coreg (Carvedilol)
  • Diabetes
  • Major surgery requiring anesthesia
Detailed risks & warnings »
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
CoregHydrochlorothiazide
  • You have to take Carvedilol with food.
  • Take it with food.
No food related info.
Kidneys and liver
CoregHydrochlorothiazide
No kidneys and liver related info.
  • Requires routine blood tests to check kidney function.
Upsides and benefits
CoregHydrochlorothiazide
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure and heart attack.
  • For people with severe heart failure, Carvedilol lowers the risk of worsening heart failure, hospitalization, and sudden death.
  • Works well to get rid of extra fluids in your body through urination.
  • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have both high blood pressure and heart failure.
  • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
  • Most people have very few side effects.
Downsides and risks
CoregHydrochlorothiazide
  • You have to take Carvedilol with food.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Carvedilol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Makes you urinate more often.
  • Doesn't work well in people with severe kidney problems.
Tips from our pharmacists for people taking the medication
CoregHydrochlorothiazide
  • Take it with food.
  • Can cause fatigue and erectile dysfunction.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Starts working in about 2 hours.
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
Learn more
More about CoregSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Coreg (Carvedilol)?
Worth itNot sureNot worth it
More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it