Compare Coreg vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coreg
(carvedilol)

Microzide
(hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Coreg (Carvedilol) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
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4.79Coreg
Reviews for Coreg (carvedilol)
53%
of people (All ages) say Coreg (carvedilol) is worth it
46%
say it works well
18%
say it's a big hassle
406 reviews
Have you used Coreg (carvedilol)?
Worth itNot sureNot worth it
Reviews for Microzide (hydrochlorothiazide )
47%
-6% worse vs. Coreg (carvedilol)
31%
-15% worse vs. Coreg (carvedilol)
16%
+2% better vs. Coreg (carvedilol)
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
Coreghydrochlorothiazide
  • Dizziness 13%
  • Fatigue 2%
  • High blood sugar 4%
  • Diarrhea 6%
  • Weight increase 3%
  • Nausea 4%
  • Abnormally slow heartbeat 8%
  • Low blood pressure 6%
  • Headache 1%
More Coreg side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Coreghydrochlorothiazide
Coreg (Carvedilol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Coreghydrochlorothiazide
Prescription only
Prescription only
Available as
Coreghydrochlorothiazide
  • Pill
  • Extended release
  • Pill
Used for
Coreghydrochlorothiazide
Risk factors for serious side effects
Coreghydrochlorothiazide
  • Abrupt discontinuation of Coreg (Carvedilol)
      • Congestive heart failure
      • Increasing the dose of Coreg (Carvedilol)
      • Diabetes
      • Major surgery requiring anesthesia
        Detailed Coreg (carvedilol) risks & warnings »
        • Current electrolyte imbalance
        • Lower kidney function
        • Dehydration
        • History of sulfa allergies
        • History of gout
        • Current kidney problems
        • History of sulfa or penicillin allergies
        • Diabetes
        Detailed Microzide (hydrochlorothiazide ) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Food
        Coreghydrochlorothiazide
        • You have to take Carvedilol with food.
        • Take it with food.
        No food related info.
        Kidneys and liver
        Coreghydrochlorothiazide
        No kidneys and liver related info.
        • Requires routine blood tests to check kidney function.
        Upsides and benefits
        Coreghydrochlorothiazide
        • A first-choice treatment to prevent chest pain (angina).
        • A first-choice treatment for heart failure and heart attack.
        • For people with severe heart failure, Carvedilol lowers the risk of worsening heart failure, hospitalization, and sudden death.
        • Does a good job getting rid of extra fluids in your body by making you urinate more.
        • A first-choice blood pressure treatment. Works especially well for people of African descent.
        • Lowers the risk of heart attack and stroke.
        • Good option if you have high blood pressure and heart failure.
        • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
        • Can be good for patients with osteoporosis since it raises the body's level of calcium.
        Downsides and risks
        Coreghydrochlorothiazide
        • You have to take Carvedilol with food.
        • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
        • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
        • Can hide symptoms of low blood sugar if you're diabetic.
        • You can't miss doses. Stopping Carvedilol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
        • Makes you urinate more often.
        • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
        • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
        • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
        Tips from our pharmacists for people taking the medication
        Coreghydrochlorothiazide
        • Take it with food.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Can cause fatigue and erectile dysfunction.
        • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
        • Don't stop taking this medicine suddenly.
        • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
        • It makes you urinate more often, so don't take it at bedtime.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
        • Requires routine blood tests to check kidney function.
        Learn more
        More about CoregSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Coreg (carvedilol)?
        Worth itNot sureNot worth it
        More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Microzide (hydrochlorothiazide )?
        Worth itNot sureNot worth it