Coming soon. Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap. How it works Coming soon. Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy. Type of medication Coming soon. Antihistamine
› 1st generation
Prescription or OTC Available as Pill Oral solution Cream, gel, or ointment Used for (click to learn more) Acute lymphoid leukemia Adrenal insufficiency Allergic disorder Chronic lymphoid leukemia Collagen disease Disorder of endocrine system Disorder of eye Disorder of gastrointestinal tract Disorder of hematopoietic structure Disorder of respiratory system Disorder of skin Hodgkin's disease Hypercalcemia of malignancy Inflammatory disorder of musculoskeletal system Mycosis fungoides Neoplastic disease Nephrotic syndrome Non-Hodgkin's lymphoma Trichinosis Tuberculosis of meninges; Adjunct Find lowest prices Save on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance. Reviews & ratings Everyone Men Women Button Group. All currently active Everyone Men Women All ages 18-34 35-54 55+ Button Group. All currently active All ages 18-34 35-54 55+
of people say cortisone is worth it say it works well say it’s a big hassle
of people say Benadryl is worth it say it works well say it’s a big hassle Side effects
We haven’t found good data for cortisone side effects.
FDA side effect reports for cortisone »
We haven’t found good data for Benadryl side effects.
FDA side effect reports for Benadryl » Risk factors for serious side effects Pregnancy category
Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.
See the FDA package insert D FDA pregnancy category (Weigh risks vs. benefits)
Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.
See the FDA package insert B FDA pregnancy category (Probably safe)
Alcohol No specific alcohol-related info. Don't take it with alcohol or other drugs that make you sleepy.
Food No specific food-related info. No specific food-related info.
Kidneys and liver No specific kidneys and liver-related info. No specific kidneys and liver-related info.
Sex No specific sex-related info. No specific sex-related info.
Sleep No specific sleep-related info. Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
Weight No specific weight-related info. No specific weight-related info. Upsides and benefits Coming soon. Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives. It can provide quick relief of allergy symptoms for both kids and adults. It makes you sleepy, so it'll help if your allergies are bothering you at night. The effects wear off in 4 to 6 hours, so side effects don't last that long. It comes as a tablet, capsule, liquid, and quick dissolving tablet. Downsides and risks Coming soon. Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec. You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you. Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child. It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine). Don't use Benadryl (Diphenhydramine) if you are breastfeeding. Tips from our pharmacists for people taking the medication Coming soon. Take it as needed every 4 to 6 hours. Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids. Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep. Don't take it with alcohol or other drugs that make you sleepy. If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term. If you only have itchy or watery eyes, try using just an antihistamine eye drop. Learn more More about cortisone Side effects Reviews & ratings FDA package insert More about Benadryl Side effects Reviews & ratings Alternatives FDA package insert