Compare Cortisone vs. Benadryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cortisone

Benadryl
(Diphenhydramine)

Coming soon.Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.
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  • Coupons for Cortisone
  • Cost for (45) 25mg tablets of Cortisone
Reviews & ratings
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Have you used Cortisone?
Worth itNot sureNot worth it
Reviews for Benadryl (Diphenhydramine)
85%
+35% vs. Cortisone
57%
+7% vs. Cortisone
8%
8% vs. Cortisone
267 reviews
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
Side effects
CortisoneBenadryl

We haven’t found good data for Cortisone side effects.

FDA side effect reports for Cortisone »

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
How it works
CortisoneBenadryl
Coming soon.Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.
Type of medication
CortisoneBenadryl
Coming soon.
Antihistamine
1st generation
Prescription or OTC
Available as
CortisoneBenadryl
  • Pill
  • Pill
  • Oral solution
  • Cream, gel, or ointment
Used for (click to learn more)
CortisoneBenadryl
  • Acute lymphoid leukemia Adrenal insufficiency Allergic disorder Chronic lymphoid leukemia Collagen disease Disorder of endocrine system Disorder of eye Disorder of gastrointestinal tract Disorder of hematopoietic structure Disorder of respiratory system Disorder of skin Hodgkin's disease Hypercalcemia of malignancy Inflammatory disorder of musculoskeletal system Mycosis fungoides Neoplastic disease Nephrotic syndrome Non-Hodgkin's lymphoma Trichinosis Tuberculosis of meninges; Adjunct
Risk factors for serious side effects
CortisoneBenadryl
Coming soon.
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
CortisoneBenadryl
No alcohol related info.
  • Don't take it with alcohol or other drugs that make you sleepy.
Sleep
CortisoneBenadryl
No sleep related info.
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
Upsides and benefits
CortisoneBenadryl
Coming soon
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
Downsides and risks
CortisoneBenadryl
Coming soon
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
Tips from our pharmacists for people taking the medication
CortisoneBenadryl
Coming soon
  • Take it as needed every 4 to 6 hours.
  • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
Learn more
More about CortisoneSide effectsReviews & ratingsFDA package insert
Have you used Cortisone?
Worth itNot sureNot worth it
More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it