Compare Cortisone vs. fludrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

No information currently available
Treats electrolyte imbalance.

Fludrocortisone is one of the first choices used in Addison's disease to help maintain your electrolytes, but there are side effects.

No information currently available
  • Fludrocortisone is effective in correcting electrolyte imbalances associated with Addison's disease.
  • Generic is available.
  • Only need to take it once daily.
No information currently available
  • Fludrocortisone can cause reactivation of old infections such as Hepatits B, C, or tuberculosis.
  • Fludrocortisone can make it easier for you to get sick.
  • Fludrocortisone can interact with other drugs and vaccines.
  • While on Fludrocortisone, you may need to have blood tests done for monitoring.
Used for
  • Acute lymphoid leukemia Adrenal insufficiency Allergic disorder Chronic lymphoid leukemia Collagen disease Disorder of endocrine system Disorder of eye Disorder of gastrointestinal tract Disorder of hematopoietic structure Disorder of respiratory system Disorder of skin Hodgkin's disease Hypercalcemia of malignancy Inflammatory disorder of musculoskeletal system Mycosis fungoides Neoplastic disease Nephrotic syndrome Non-Hodgkin's lymphoma Trichinosis Tuberculosis of meninges; Adjunct
  • Addison's disease
  • Congential adrenal hyperplasia
Dosage forms
  • Pill
  • Pill
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Side effects
The Cortisone FDA package insert doesn’t have numbers about how common side effects are.
The Fludrocortisone FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Lowered adrenal function
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection
  • Increased risk for infections
    • Taking other immunosuppressants
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in electrolyte balance
  • Eye problems
  • Bone effects
    • Dose of Fludrocortisone
    • Duration of treatment
  • Stomach and intestinal problems
    • History of stomach bleeding
    • Active or history of stomach ulcers
    • Ulcerative colitis
    • Taking Fludrocortisone with other medicine that can cause stomach problems
See more detailed risks and warnings