Compare Cortisone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Coming soon.Calms down your immune system. Medrol (Methylprednisolone) is corticosteroid available in many forms (oral, injectable) that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.
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  • Cost for (45) 25mg tablets of Cortisone
Reviews & ratings
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Have you used Cortisone?
Worth itNot sureNot worth it
Reviews for Medrol (Methylprednisolone)
+7% vs. Cortisone
+1% vs. Cortisone
23% vs. Cortisone
Have you used Medrol (Methylprednisolone)?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Cortisone side effects.

FDA side effect reports for Cortisone »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »
How it works
Coming soon.Medrol (Methylprednisolone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.
Type of medication
Coming soon.
Anti-inflammatory, Immunosuppressant
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
  • Acute lymphoid leukemia Adrenal insufficiency Allergic disorder Chronic lymphoid leukemia Collagen disease Disorder of endocrine system Disorder of eye Disorder of gastrointestinal tract Disorder of hematopoietic structure Disorder of respiratory system Disorder of skin Hodgkin's disease Hypercalcemia of malignancy Inflammatory disorder of musculoskeletal system Mycosis fungoides Neoplastic disease Nephrotic syndrome Non-Hodgkin's lymphoma Trichinosis Tuberculosis of meninges; Adjunct
Risk factors for serious side effects
Coming soon.
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Duration of treatment
    • History of psychiatric conditions
    • Dose of Medrol (Methylprednisolone)
    • Duration of treatment
    • Women of childbearing age
    • History of stomach bleeding
    • Active or history of stomach or duodenal ulcers
    • Ulcerative colitis
    • Taking Medrol (Methylprednisolone) with other medicine that can cause stomach problems
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
    Detailed Medrol (Methylprednisolone) risks & warnings »

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    No food related info.
    • Take with food to decrease stomach upset.
    Kidneys and liver
    No kidneys and liver related info.
    • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Medrol (Methylprednisolone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Medrol (Methylprednisolone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
    Upsides and benefits
    Coming soon
    • Steroid magic, can help you feel better, have more energy and get more appetite.
    • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
    • Useful in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
    • Available in many different forms, including injection, that will expose the rest of your body less of the medicine.
    Downsides and risks
    Coming soon
    • Lots of side effects, especially with long term use.
    • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
    • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
    • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Medrol.
    • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
    Tips from our pharmacists for people taking the medication
    Coming soon
    • The dose and duration on how long you need the medicine depends on your condition and response.
    • Take it exactly as your doctor prescribed.
    • Take with food to decrease stomach upset.
    • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
    • Can cause changes in mood, blood pressure, blood sugar, and water retention.
    • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
    • A taper is often needed to stop the medicine, especially if you've been on it for more than 1 week.
    Learn more
    More about CortisoneSide effectsReviews & ratingsFDA package insert
    Have you used Cortisone?
    Worth itNot sureNot worth it
    More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Medrol (Methylprednisolone)?
    Worth itNot sureNot worth it